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Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease

Hypertension Researchvolume 42pages123140 (2019) | Download Citation

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Abstract

The health and proper functioning of the cardiovascular and renal systems largely depend on crosstalk in the gut–kidney–heart/vessel triangle. Recent evidence suggests that the gut microbiota has an integral function in this crosstalk. Mounting evidence indicates that the development of chronic kidney and cardiovascular diseases follows chronic inflammatory processes that are affected by the gut microbiota via various immune, metabolic, endocrine, and neurologic pathways. Additionally, deterioration of the function of the cardiovascular and renal systems has been reported to disrupt the original gut microbiota composition, further contributing to the advancement of chronic cardiovascular and renal diseases. Considering the interaction between the gut microbiota and the renal and cardiovascular systems, we can infer that interventions for the gut microbiota through diet and possibly some medications can prevent/stop the vicious cycle between the gut microbiota and the cardiovascular/renal systems, leading to a decrease in chronic cardiovascular and renal diseases.

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Affiliations

  1. Department of Medicine, Koc University School of Medicine, Istanbul, Turkey

    • Emine M. Onal
  2. Department of Medicine, Division of Nephrology, Suleyman Demirel University School of Medicine, Isparta, Turkey

    • Baris Afsar
  3. Nephrology Clinic, Dialysis and Renal Transplant Center, ‘C.I. PARHON’ University Hospital, and ‘Grigore T. Popa’ University of Medicine, Iasi, Romania

    • Adrian Covic
  4. Division of Nephrology and Hypertension, Schools of Medicine and Biological Science, University of California, California, CA, USA

    • Nosratola D. Vaziri
  5. Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey

    • Mehmet Kanbay

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All authors approved the final version of the manuscript.

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The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Mehmet Kanbay.

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DOI

https://doi.org/10.1038/s41440-018-0144-z