a, b Brain MRI of the patient’s mother (a, FLIAR image; b, T2* image). Note that the patient’s mother showed moderate brain atrophy. c, d Brain MRI of the patient’s sister (c FLAIR image; d T2* image). e, f MRI characteristics of the glioblastoma in the index patient (e FLAIR image; f gadolinium-enhanced T1-weighted image). g The resected brain tissue stained with hematoxylin and eosin. Note the marked hypercellularity, nuclear atypia, microvascular proliferation, and necrosis. Bar = 100 µm.