Table 4 Overall results for men with no prior genetic testing/screening.

From: Diagnosing hereditary cancer predisposition in men with prostate cancer

  ProstateNext     Other MGPT  
N 277     1385  
Overall test result (%)       
 Positive 26   9.4%   168 12.1%
 Inconclusive 44   15.9%   324 23.4%
 Moderate risk PV 2   0.7%   13 0.9%
MUTYH carrier 0   0.0%   17 1.2%
 Negative 205   74.0%   863 62.3%
Gene PV/VLP Total # tested % PV/VLP Total # tested %
BRCA2 9 277 3.2% 47 1224 3.8%
BRCA1 1 277 0.4% 9 1223 0.7%
TP53 1 277 0.4% 4 1367 0.3%
MLH1 0 277 0.0% 2 1224 0.2%
MSH2 0 277 0.0% 11 1224 0.9%
MSH6 0 277 0.0% 5 1224 0.4%
PMS2 0 277 0.0% 7 1224 0.6%
EPCAM 0 277 0.0% 1 1222 0.1%
CHEK2 3 277 1.1% 35 1199 2.9%
PALB2 1 277 0.4% 6 1169 0.5%
ATM 5 277 1.8% 32 1145 2.8%
NBN 2 277 0.7% 2 1057 0.2%
RAD51D 0 277 0.0% 0 1031 0.0%
MUTYH 0 0 - 23 1151 2.0%
BRIP1 0 0 - 1 1037 0.1%
RAD51C 0 0 - 1 1038 0.1%
MRE11A 0 0 - 2 1031 0.2%
BARD1 0 0 - 3 1030 0.3%
APC 0 0 - 8 1004 0.8%
CDKN2A 0 0 - 5 867 0.6%
HOXB13 6 277 2.2% 2 339 0.6%
SDHD 0 0 - 1 293 0.3%
MITF 0 0 - 3 291 1.0%
FH 0 0 - 1 288 0.3%
FLCN 0 0 - 1 283 0.4%
MAX 0 0 - 1 251 0.4%
BAP1 0 0 - 1 244 0.4%
FANCC 0 0 - 1 84 1.2%