Table 3 Most informative variables for prediction of positive result.

From: Diagnosing hereditary cancer predisposition in men with prostate cancer

Stepwise coefficientsa,b
  Estimate Pr(>|z|) OR (95% CI)
Gleason score (numeric) 0.1702 0.096 1.19 (0.97, 1.45)
Personal history: breast or pancreatic cancer 1.2863 0.0082 3.62 (1.37, 9.46)
>1 relative with breast, ovarian, or pancreatic cancer 0.843 2.34E-04 2.32 (1.48, 3.65)
>1 relative with Lynch-related cancer (includes colorectal, endometrial, gastric, ovarian, pancreatic, small bowel, urothelial, kidney, or bile duct cancer) 0.6803 0.0044 1.97 (1.23, 3.15)
  1. aThe variables presented here are adjusted for all other variables in the table.
  2. bNote: “panel tested”, “meet HBOC criteria”, “meet Lynch criteria”, “meet Hopkins FPC criteria” and “metastatic” are not included in any models; all other univariate predictors in Table 2 are included as potential predictors in the selecting procedure: Ashkenazi ethnicity (yes/no); age at prostate cancer (PC); personal history of other cancer; personal history: breast, pancreatic cancer; family history of cancer; family history of cancer first-degree relative (FDR) only; family history of cancer FDR/second-degree relative (SDR); family history of PC; family history of PC FDR only; >1 relative with breast, ovarian, or pancreatic cancer; >1 relative with Lynch-related cancer (includes colorectal, endometrial, gastric, ovarian, pancreatic, small bowel, urothelial, kidney, or bile duct cancer); Gleason score; Gleason score (level 1); Gleason score (level 2), Gleason score (level 3).