Table 3 Odds ratios and corresponding 95% confidence intervals for family history predictors of BRCA1 and BRCA2 pathogenic variant carrier status

From: Classification of variants of uncertain significance in BRCA1 and BRCA2 using personal and family history of cancer from individuals in a large hereditary cancer multigene panel testing cohort

No. of 1st/2nd relativesBRCA1BRCA2
With BC <50 (vs. 0)CaucasianAfrican AmericanAsianHispanicCaucasianAfrican AmericanAsianHispanic
 12.2 (2.0, 2.4)3.1 (2.2, 4.4)2.8 (1.7, 4.5)2.7 (1.9, 3.9)1.5 (1.3, 1.7)1.3 (0.9, 1.8)1.3 (0.8, 2.0)1.5 (1.0, 2.2)
 23.7 (3.1, 4.4)5.1 (3.2, 8.2)3.0 (1.3, 7.2)5.0 (2.9, 8.7)2.0 (1.6, 2.4)1.4 (0.8, 2.4)1.5 (0.7, 3.5)1.3 (0.7, 2.7)
 3+5.3 (4.0, 7.0)12.0 (6.5, 22.1)8.3 (2.2, 32.1)9.1 (4.4, 18.9)3.2 (2.4, 4.3)1.8 (0.7, 4.5)3.1 (0.7, 13.9)3.4 (1.4, 8.2)
BC ≥50 (vs. 0)        
 10.9 (0.8, 1.1)0.7 (0.5, 1.0)1.5 (0.9, 2.3)1.1 (0.7, 1.5)1.1 (0.9, 1.2)0.8 (0.6, 1.2)2.4 (1.6, 3.6)1.3 (0.9, 1.9)
 20.7 (0.6, 0.8)0.5 (0.2, 1.0)0.6 (0.2, 2.0)0.7 (0.4, 1.4)0.9 (0.8, 1.1)0.8 (0.5, 1.3)1.4 (0.6, 3.0)0.9 (0.5, 1.7)
 3+0.7 (0.5, 1.0)0.7 (0.2, 1.9)2.0 (0.4, 8.8)0.9 (0.3, 2.7)0.7 (0.6, 1.0)1.4 (0.7, 2.6)3.0 (1.1, 7.8)0.4 (0.1, 1.6)
OC <60 (vs. 0)        
 13.2 (2.8, 3.7)1.7 (1.0, 2.9)3.4 (1.9, 6.2)1.9 (1.2, 2.9)1.4 (1.2, 1.7)2.1 (1.3, 3.2)1.5 (0.8, 2.8)1.4 (0.8, 2.2)
 2+5.4 (4.1, 7.1)0.4 (0.0, 2.9)4.8 (1.2, 19.1)3.0 (1.4, 6.6)1.4 (0.9, 2.1)0.6 (0.1, 4.2)1.0 (0.1, 7.6)1.0 (0.3, 3.4)
OC ≥60 (vs. 0)        
 11.7 (1.4, 2.0)2.3 (1.2, 4.1)1.8 (0.8, 4.1)1.9 (1.0, 3.6)1.6 (1.3, 1.8)0.7 (0.3, 1.5)1.2 (0.6, 2.6)1.5 (0.8, 2.9)
 2+1.6 (0.9, 2.8)2.7 (0.6, 12.5)5.6 (1.3, 25.0)2.0 (0.3, 15.4)1.9 (1.2, 3.0)1.0 (0.1, 7.1)1.6 (0.4, 7.0)
Pancreatic cancer        
 11.1 (0.9, 1.3)0.9 (0.5, 1.6)0.7 (0.2, 1.9)1.2 (0.7, 2.3)1.3 (1.1, 1.5)1.6 (1.0, 2.5)1.7 (0.9, 3.1)2.1 (1.3, 3.3)
 2+0.7 (0.4, 1.1)2.0 (0.7, 5.5)1.3 (0.2, 10.0)2.6 (1.0, 6.6)1.7 (1.3, 2.2)1.1 (0.3, 3.6)0.6 (0.1, 4.5)0.4 (0.1, 2.9)
MBC1.0 (0.7, 1.5)0.9 (0.2, 3.7)0.4 (0.0, 3.1)2.5 (1.9, 3.1)5.4 (3.0, 9.7)3.1 (1.3, 7.5)
Prostate (vs. 0)        
 10.9 (0.8, 1.1)0.4 (0.2, 0.7)0.9 (0.4, 1.9)0.8 (0.5, 1.3)1.3 (1.2, 1.5)1.2 (0.8, 1.7)1.8 (1.1, 3.0)1.3 (0.8, 2.0)
 2+0.7 (0.5, 0.9)0.5 (0.2, 1.1)0.5 (0.1, 4.3)0.4 (0.1, 1.4)1.5 (1.3, 1.8)0.9 (0.5, 1.6)1.9 (0.6, 6.7)2.1 (1.1, 3.9)
Total model AUC0.79 (0.77–0.80)0.83 (0.80–0.86)0.79 (0.74–0.83)0.82 (0.79–0.85)0.67 (0.66–0.69)0.68 (0.64–0.72)0.70 (0.65–0.75)0.66 (0.62–0.71)
  1. AUC area under the curve, BC breast cancer, MBC male breast cancer, OC ovarian cancer.