Table 1 Number of individuals and variants included in the study by gene and classification

From: Classification of variants of uncertain significance in BRCA1 and BRCA2 using personal and family history of cancer from individuals in a large hereditary cancer multigene panel testing cohort

GeneRacial/ethnic groupTestedPathogenicVLPVUSNo variant
BRCA1aEuropean95,60714575282493,274
Mixed/unknown15,7962492019915,328
African American8545193101668176
Asian5274105171704982
Hispanic769318910957399
Total132,91521931091454129,159
BRCA2bEuropean96,641154686173593,274
Mixed/unknown16,0252811739915,328
African American8734201103478176
Asian537111842674982
Hispanic777516072097399
Total134,54623061242957129,159
  1. VLP likely pathogenic variant, VUS variant of unknown significance.
  2. aExcludes individuals with pathogenic or VUS/VLP variants in BRCA2.
  3. bExcludes individuals with pathogenic or VUS/VLP variants in BRCA1.