Estimated survival distributions and age of disease onset for patients with Krabbe disease. (a) Estimated survival distribution for patients with Krabbe disease per subtype (N = 173). Censored individuals are marked with a “+.” (b) Estimated survival distribution for Krabbe disease patients with a cerebrospinal fluid (CSF) protein concentration above 61.5 mg/dl (N = 34, black line) and below or equal to 61.5 mg/dl (N = 14, gray line). Censored individuals are marked with a “+.” Log-rank test, p = 0.002. (c) Age of disease onset/Krabbe disease subtype subject to CSF protein content (mg/dl). Data were available for N = 28 patients in the early infantile, N = 12 in both late infantile and juvenile groups and N = 7 in the adult onset group. Black lines indicate the median per group, single dots individual extreme values.