Collins FS, McKusick VA. Implications of the Human Genome Project for medical science. JAMA. 2001;285:540–544.
Subramanian G, Adams MD, Venter JC, Broder S. Implications of the human genome for understanding human biology and medicine. JAMA. 2001;286:2296–2307.
Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372:793–795.
McCarthy JJ, McLeod HL, Ginsburg GS. Genomic medicine: a decade of successes, challenges, and opportunities. Sci Transl Med. 2013;5:189sr184.
Green ED, Guyer MS. National Human Genome Research I. Charting a course for genomic medicine from base pairs to bedside. Nature. 2011;470:204–213.
Ginsburg GS, Willard HF. Genomic and personalized medicine: foundations and applications. Transl Res. 2009;154:277–287.
Relling MV, Evans WE. Pharmacogenomics in the clinic. Nature. 2015;526:343–350.
Manolio TA, Chisholm RL, Ozenberger B, et al. Implementing genomic medicine in the clinic: the future is here. Genet Med. 2013;15:258–267.
Hofman V, Ilie M, Long E, et al. Detection of circulating tumor cells from lung cancer patients in the era of targeted therapy: promises, drawbacks and pitfalls. Curr Mol Med. 2014;14:440–456.
Burke W, Korngiebel DM. Closing the gap between knowledge and clinical application: challenges for genomic translation. PLoS Genet. 2015;11:e1004978.
Williams MS. Genomic medicine implementation: learning by example. Am J Med Genet C Semin Med Genet. 2014;166C:8–14.
Sperber NR, Carpenter JS, Cavallari LH, et al. Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network. BMC Med Genom. 2017;10:35.
Grosse SD, McBride CM, Evans JP, Khoury MJ. Personal utility and genomic information: look before you leap. Genet Med. 2009;11:575–576.
Bunnik EM, Janssens AC, Schermer MH. Personal utility in genomic testing: is there such a thing? J Med Ethics. 2015;41:322–326.
Botkin JR, Teutsch SM, Kaye CI, et al. Outcomes of interest in evidence-based evaluations of genetic tests. Genet Med. 2010;12:228–235.
Hofman KJ, Tambor ES, Chase GA, Geller G, Faden RR, Holtzman NA. Physicians’ knowledge of genetics and genetic tests. Acad Med. 1993;68:625–632.
Hayflick SJ, Eiff MP. Role of primary care providers in the delivery of genetics services. Community Genet. 1998;1:18–22.
Suther S, Goodson P. Barriers to the provision of genetic services by primary care physicians: a systematic review of the literature. Genet Med. 2003;5:70–76.
Weipert CM, Ryan KA, Everett JN, et al. Physician experiences and understanding of genomic sequencing in oncology. J Genet Couns. 2018;27:187-196. https://doi.org/10.1007/s10897-017-0134-3.
Vassy JL, Green RC, Lehmann LS. Genomic medicine in primary care: barriers and assets. Postgrad Med J. 2013;89:615–616.
Mikat-Stevens NA, Larson IA, Tarini BA. Primary-care providers’ perceived barriers to integration of genetics services: a systematic review of the literature. Genet Med. 2015;17:169–176.
Chow-White P, Ha D, Laskin J. Knowledge, attitudes, and values among physicians working with clinical genomics: a survey of medical oncologists. Hum Resour Health. 2017;15:42.
Hazin R, Brothers KB, Malin BA, et al. Ethical, legal, and social implications of incorporating genomic information into electronic health records. Genet Med. 2013;15:810–816.
Weitzel KW, Alexander M, Bernhardt BA, et al. The IGNITE network: a model for genomic medicine implementation and research. BMC Med Genom. 2016;9:1.
Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50.
Huberman AM, Miles MB. Understanding and validity in qualitative research. In: Huberman AM, Miles MBThe qualitative researcher’s companion. Thousand Oaks, CA: SAGE; 2002. p. 36–65.
Luzum JA, Pakyz RE, Elsey AR, et al. The Pharmacogenomics Research Network Translational Pharmacogenetics Program: outcomes and metrics of pharmacogenetic implementations across diverse healthcare systems. Clin Pharmacol Ther. 2017;102:502–510.
Shuldiner AR, Relling MV, Peterson JF, et al. The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation. Clin Pharmacol Ther. 2013;94:207–210.
Gottesman O, Kuivaniemi H, Tromp G, et al. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med. 2013;15:761–771.
Hamilton AB, Oishi S, Yano EM, Gammage CE, Marshall NJ, Scheuner MT. Factors influencing organizational adoption and implementation of clinical genetic services. Genet Med. 2014;16:238–245.