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MDSC expansion during HIV infection: regulators, ART and immune reconstitution

Abstract

Myeloid-derived suppressor cells (MDSCs) become expanded in different pathological conditions including human immunodeficiency virus (HIV) infection and this may worsen the disease status and accelerate disease progression. In HIV infection, MDSCs suppress anti-HIV immune responses and hamper immune reconstitution. Understanding the factors and mechanisms of MDSC expansion during HIV infection is central to understanding the pathophysiology of HIV infection. This may pave the way to developing new therapeutic targets or strategies. In this work we addressed (i) the mechanisms that regulate MDSC expansion, (ii) the impact of antiretroviral therapy (ART) on the frequency of MDSCs during HIV infection; (iii) the impact of MDSCs on immune reconstitution during successful ART; and (iv) the potential of MDSCs as a therapeutic target.

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Fig. 1: A proposed scenario describing MDSC expansion during HIV infection.

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MMY contributed to writing all sections. NMA contributed to writing the introduction and conclusion. HD contributed to writing the introduction. MMY, NMA, and HD critically reviewed and validated the final version of this paper.

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Yaseen, M.M., Abuharfeil, N.M. & Darmani, H. MDSC expansion during HIV infection: regulators, ART and immune reconstitution. Genes Immun 25, 242–253 (2024). https://doi.org/10.1038/s41435-024-00272-9

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