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CRISPR editing as a therapeutic strategy for Duchenne muscular dystrophy—anti-Cas9 immune response casts its shadow over safety and efficacy

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Fig. 1: Anti-Cas9 immunity and its impact on CRISPR editing in a DMD dog model.

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Acknowledgements

The author thanks Zachary Coulson for generating the figure, and for helpful review of the manuscript.

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JJD conceived, wrote, edited, and finalized all aspects of this manuscript. Zachary Coulson helped generated the figure (see acknowledgements).

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Correspondence to James J. Dowling.

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Dowling, J.J. CRISPR editing as a therapeutic strategy for Duchenne muscular dystrophy—anti-Cas9 immune response casts its shadow over safety and efficacy. Gene Ther 29, 575–577 (2022). https://doi.org/10.1038/s41434-022-00323-8

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