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Gene therapy for cardiovascular diseases in China: basic research

Gene Therapy volume 27, pages 360–369 (2020)Cite this article

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Abstract

Cardiovascular disease has become a major disease affecting health in the whole world. Gene therapy, delivering foreign normal genes into target cells to repair damages caused by defects and abnormal genes, shows broad prospects in treating different kinds of cardiovascular diseases. China has achieved great progress of basic gene therapy researches and pathogenesis of cardiovascular diseases in recent years. This review will summarize the latest research about gene therapy of proteins, epigenetics, including noncoding RNAs and genome-editing technology in myocardial infarction, cardiac ischemia–reperfusion injury, atherosclerosis, muscle atrophy, and so on in China. We wish to highlight some important findings about the essential roles of basic gene therapy in this field, which might be helpful for searching potential therapeutic targets for cardiovascular disease.

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Acknowledgements

This work was supported by the grants from the National Natural Science Foundation of China (81722008 and 81911540486 to JX, 81700761 to JD), Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-09-E00042 to JX), the grant from Science and Technology Commission of Shanghai Municipality (18410722200 and 17010500100 to JX), National Key Research and Development Project (2018YFE0113500 to JX), and the “Dawn” Program of Shanghai Education Commission (19SG34 to JX). Due to the limited layout, many excellent researches have not been included, but thanks for their contributions.

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  1. Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, 200444, China

    Jiali Deng, Mengying Guo & Junjie Xiao

  2. School of Medicine, Shanghai University, Shanghai, 200444, China

    Mengying Guo & Junjie Xiao

  3. Cardiovascular Division of the Massachusetts, General Hospital and Harvard Medical School, Boston, MA, 02215, USA

    Guoping Li

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Deng, J., Guo, M., Li, G. et al. Gene therapy for cardiovascular diseases in China: basic research. Gene Ther 27, 360–369 (2020). https://doi.org/10.1038/s41434-020-0148-6

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