Improved therapeutic potential of MSCs by genetic modification

Abstract

Mesenchymal stem cells (MSCs), well-studied adult stem cells in various tissues, possess multi-lineage differentiation potential and anti-inflammatory properties. MSCs have been approved to regenerate lineage-specific cells to replace injured cells in tissues. MSCs are approved to treat inflammatory diseases. With the discovery of genes important for the repair of damaged tissues, MSCs genetically modified by such genes hold improved therapeutic potential. In this review, we summarised the uses of genetically modified MSCs to treat different diseases, including bone diseases, cardiovascular diseases, autoimmune diseases, central nervous system disorders, and cancer. To better understand the exact role of genetically modified MSCs, key mechanisms determining, which genes are selected to be used for modifying MSCs and improvements in post-genetic modification are discussed. Therapeutic benefits enhanced by genetic modifications are to be documented by further clinical studies.

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Acknowledgements

This work is supported by the National High-tech R&D programme (863 Programme) 2014AA020704 and the National Natural and Scientific Foundation of China, 81400057/H0111, 81572981/H1611, 81123003/H1604, 81201789/H1611 81672397/H1617.

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Correspondence to Wei Wang.

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Wei, W., Huang, Y., Li, D. et al. Improved therapeutic potential of MSCs by genetic modification. Gene Ther 25, 538–547 (2018). https://doi.org/10.1038/s41434-018-0041-8

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