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Comment on: ‘Short-term outcomes of Mitomycin-C augmented phaco-trabeculectomy using subconjunctival injections versus soaked sponges: a randomized controlled trial’

Eye (2024)Cite this article

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We read with great interest the article by Chakrabarty et al. [1], which reported that subconjunctival injection of mitomycin C (MMC) resulted in a greater reduction in intraocular pressure compared to sponge-based MMC augmentation for trabeculectomy in the short term. However, we would like to point out three concerns regarding this paper.

First, it is advisable to introduce the change in intraocular pressure (IOP) from baseline (mmHg), which is commonly used in many studies to evaluate surgical efficacy [2, 3]. At 6 months postoperatively, a significant difference was observed between the two groups; however, the difference was relatively minimal. Both groups experienced a reduction of approximately 10 mmHg in IOP from baseline, suggesting that the impact on IOP was comparable between the two procedures. Therefore, incorporating the change in IOP from baseline could further enhance readers’ understanding of this topic.

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References

  1. Chakrabarty S, Kader MA, Maheshwari D, Pillai MR, Chandrashekharan S, Ramakrishnan R. Short-term outcomes of Mitomycin-C augmented phaco-trabeculectomy using subconjunctival injections versus soaked sponges: a randomized controlled trial. Eye. 2024;38:1196–201. https://doi.org/10.1038/s41433-023-02869-2.

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  3. Zhang ML, Hirunyachote P, Jampel H. Combined surgery versus cataract surgery alone for eyes with cataract and glaucoma. Cochrane Database Systematic Rev. 2015. https://doi.org/10.1002/14651858.CD008671.pub3.

  4. Holló G. Wound Healing and Glaucoma Surgery: Modulating the Scarring Process with Conventional Antimetabolites and New Molecules. Dev Ophthalmol. 2017;59:80–9. https://doi.org/10.1159/000458488.

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Authors and Affiliations

  1. Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan

    Yuto Yoshida

  2. Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima, Japan

    Shunsuke Taito

  3. Scientific Research WorkS Peer Support Group (SRWS-PSG), Osaka, Japan

    Shunsuke Taito & Takashi Fujiwara

  4. Departement of Otolaryngology, Kurashiki Central Hospital, Okayama, Japan

    Takashi Fujiwara

Authors
  1. Yuto Yoshida
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  2. Shunsuke Taito
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  3. Takashi Fujiwara
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Contributions

YY – Literature review, writing of original draft, and revision of final submission. ST & TF – Conceptualization, review, and supervision.

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Correspondence to Yuto Yoshida.

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Yoshida, Y., Taito, S. & Fujiwara, T. Comment on: ‘Short-term outcomes of Mitomycin-C augmented phaco-trabeculectomy using subconjunctival injections versus soaked sponges: a randomized controlled trial’. Eye (2024). https://doi.org/10.1038/s41433-024-03235-6

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  • DOI: https://doi.org/10.1038/s41433-024-03235-6

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