Managing idiopathic intracranial hypertension in the eye clinic

Idiopathic intracranial hypertension (IIH) is a neuro-ophthalmological condition characterised by a raised intracranial pressure and papilloedema that causes disabling headaches. The main risk factors of female sex and living with obesity have been known for some time, however the knowledge of the underlying pathophysiology is evolving. Papilloedema can impact the visual function, and the majority of people are offered acetazolamide. Those with sight threatening disease need urgent management, though there is little high quality evidence to recommend any particular surgical intervention. Headache treatment is an unmet clinical need and simple medication overuse advice has the potential to reduce the chronification of migraine-like headaches. IIH is emerging as a systemic metabolic disease distinct from people living with obesity alone. While weight loss is the main stay of disease modifying therapy this is challenging to access and many healthcare professionals that manage the condition have no formal training or accessible pathways for weight management. The aim of this “how to do it” article is to present the latest advances in knowledge of IIH that we pragmatically included in routine clinical care for people living with the condition.

Idiopathic intracranial hypertension (IIH) is a syndrome of elevated intracranial pressure (ICP) with specific diagnostic criteria [1,2].It occurs most commonly in young women and there is evidence of dysregulated androgens [3].It is principally associated with obesity [4], however there are systemic metabolic findings which are unique to IIH, that are not conferred by living with obesity alone [5][6][7][8][9].The incidence of IIH is increasing worldwide [10][11][12], and as many ophthalmologists now diagnose and manage IIH, high quality research and practice guidelines are required to provide excellence and equity of care [13][14][15].Both physicians and patients are central to improving care and identifying those areas which require a change in practice [13,14,16].In this "how to do it" article the foundations of managing IIH in ophthalmology outpatients have been considered through a case based approach.As IIH in childhood (prepuberty) [17] and IIH without papilloedema [18] are expectantly different conditions, this article will focus on adults with IIH.This is an outline of how IIH is managed in our ophthalmology clinics, though others may prefer a different approach.

APPROACHING THE HISTORY
Patients typically report new onset headaches or a change in their existing headache frequency (approximately 90%) [19,20].Early in the disease headaches can be typical of a raised ICP headache that is worse on waking [20][21][22], however over time, for the majority, they become chronic [23].These headaches are typically migraine-like and are often accompanied with symptoms of photophobia, phonophobia and nausea [23].Transient visual obscurations (68%), back pain (53%) and pulsatile tinnitus (52%) are commonly reported [24].Approximately 33% present with loss of vision [24], and a lower percentage notes diplopia secondary to sixth nerve palsy.Facial nerve palsy is a rare occurrence.

MAKING A DEFINITE DIAGNOSIS
Despite clear diagnostic criteria which are widely accepted [1], there is evidence of diagnostic difficulty for some in confirming a diagnosis of IIH [25].One of the major stumbling points is the correct identification of papilloedema [25].Hence a full ophthalmic examination is required to confirm papilloedema and rule out pseudopapilloedema [14,15].Common causes of pseudopapilloedema include optic nerve head drusen; anomalous discs; hypermetropia and myopia.Autofluorescence, either from a fundus camera or by optical coherence tomography imaging, can highlight surface drusen.OCT can be helpful, particularly cross sectional imaging to identify buried drusen [26], and peripapillary hyperreflective ovoid mass structures (PHOMS) which may elevate the optic nerve head.Occasionally fundus fluorescein angiography (FFA) might be useful if the diagnosis is uncertain, as early capillary dilation may be observed by followed by late leakage at the optic disc [27,28].

CASE 1
A 42-year-old woman living with obesity (body mass index (BMI) 46 kg/m 2 ), and 23 kg weight gain over the past year, reports persistent daily headaches for the last two months, worse upon awakening in the morning.She denies pulsatile tinnitus, diplopia or changes in vision.She had no recent changes to medications or takes vitamin supplements.On examination, best-corrected visual acuity (BCVA) was 6/6, with all the Ishihara colour plates identified correctly in each eye.Pupils were briskly reactive with no relative afferent pupillary defect (RAPD).Ocular motility was full with no misalignment.Fundoscopy revealed mild bilateral optic nerve oedema (Fig. 1).Humphrey 30-2 perimetry showed mild enlargement of the blind spot bilaterally (Fig. 1).

INVESTIGATIONS FOR PAPILLOEDEMA
Following confirmation of true disc oedema, if it has not yet occurred, a full examination of the extent of visual dysfunction should be made.This includes visual acuity, pupil assessment, colour vision and formal visual fields.Bilateral optic nerve oedema with spared visual function is suggestive of papilloedema (optic nerve oedema secondary to elevated ICP).Papilloedema indicates a possible serious underlying condition that requires immediate work up.The first step is to check blood pressure to rule out malignant hypertension.Neuroimaging is then required, and a preferred modality by the authors is magnetic resonance imaging (MRI) of the brain and orbits, with fat suppression technique, with and without contrast.The addition of the orbital imaging allows exclusion of other optic neuropathies, however, has the drawback of a longer examination.MR venogram (MRV) with contrast is performed at the same time.Studies are intended to rule out mass lesion, hydrocephalus, meningeal infiltration, Chiari malformation and venous sinus thrombosis.If MR imaging is not available, the patient has a contraindication or suffers from claustrophobia, a contrast -enhanced computed tomography (CT)/CTV scan is as good an alternative.In this case the brain and orbit MRI with or without contrast showed a partially empty sella and was otherwise unremarkable.Contrast enhanced MRV of the brain was normal, with no evidence of venous sinus thrombosis.
A lumbar puncture (LP) is then a recommended investigation.When discussing with colleagues to arrange the LP, it is important to request that the LP be performed in the left lateral decubitus position and contents taken for protein, glucose and culture.A paired serum glucose should be taken at the same time.The opening pressure should be recorded, and above 25 cm of water (H 2 O) is considered abnormally high [14,29].There is controversy over the point at which the LP opening pressure becomes pathological, therefore if the LP opening pressure is between 25 and 30 cm H 2 O most neuro-ophthalmologists may re-evaluate the diagnosis [14,29].In case 1 the LP opening pressure was 33 cm H 2 O and cerebrospinal fluid (CSF) constituents were normal.A definite diagnosis of IIH was made as per the diagnostic criteria (Table 1) [1].
In this investigational phase, it is important to exclude anaemia, as 10% of people with papilloedema will have treatable iron deficiency anaemia [30][31][32].Of note if the haemoglobin is pathologically low, not only should investigations for the source of blood loss be investigated, a transfusion of iron and/or blood may be required.Case series have shown that reversal of papilloedema occurs with normalisation of the haemoglobin [30,31].A careful drug history should be considered in all, as a systematic review found the strongest relationship with Vitamin A derivatives, tetracycline-class antibiotics, recombinant growth hormone, and lithium, being associated with secondary raised ICP [33].This almost exclusively occurs in a temporal relationship to commencing the medication.
While the investigations are underway the patient often finds themselves under physicians who may not routinely care for people with IIH or be well versed in ophthalmology.It is therefore critically important that the ophthalmologist is in charge of the vision and re-examines the visual function as, for some, (around 7%), a rapid decline in visual function can occur [11,34].Depending on the grade of papilloedema and potential for visual loss, an escalating dose of acetazolamide may be required [14].Pathways where the patient is discharged from investigations without an assessment on whether medical management is immediately required should not occur.

DELIVERING A DIAGNOSIS OF IIH
Ideally delivering a diagnosis of IIH should be done by professionals with experience of the condition, however it usually happens in non-ideal conditions [16].It is helpful to gain knowledge of what the patient already knows about their investigations and whether they have heard of IIH.IIH UK, a patient charity, is a useful resource with the ability for the patient to connect with non-medical people for advice.IIH UK have useful patient and healthcare professional information leaflets (these can be found at https://www.iih.org.uk/product/11/2/leaflets (last accessed 28 March 2024)).Severe and complex obesity services (including obesity surgery, obesity medicine MDTs, specialist weight management programmes, post-surgical and annual follow up).It is important to note that tier 4 includes not only bariatric surgery but also bariatric medicine a Note exclusions may apply and some regional criteria may have different BMI categories.
b Tier 4 services have other inclusion criteria based for people with live with type 2 diabetes mellitus.

MANAGEMENT OF IIH
The main principles of treatment of IIH are to: 1. Protect vision 2. Treat the underlying cause 3. Reduce headache morbidity [14] WHEN TO USE ACETAZOLAMIDE The use of acetazolamide, a carbonic anhydrase inhibitor, is the most widespread treatment currently used to treat IIH to help with reduction of ICP and to protect the vision.Most physicians start treatment with a dose of between 250 and 500 mg twice a day, and escalate to between 2 g and 4 g in a daily divided dose.
In 2014 the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) [35] provided evidence that acetazolamide, in association with weight loss, was effective in reducing ICP and improving papilloedema in patients with mild to moderate visual field changes and was safe and well tolerated at doses up to 4 g/day.It did not show consistent beneficial effect on headache severity.In cases with improvement of papilloedema and stabilisation of visual fields, continuing headaches may require additional medication.We monitor response to treatment closely initially and titrate as needed.It is fundamental to discuss with the patient the medication's possible side effects: paraesthesia, dysgeusia (metallic taste), vomiting and diarrhoea, nausea, fatigue, depression and kidney stones.Their knowledge of side effects and strategies to help with its management will help with treatment compliance.Drug labelling recommends monitoring electrolytes periodically while patients are on treatment with acetazolamide, but there is no guidance regarding how frequently.Most patients will develop a chronic compensated metabolic acidosis and potassium decreases mildly.

WHEN AND HOW TO TALK ABOUT WEIGHT MANAGEMENT
Central to the care of a person with IIH is a sensitive discussion about the role of body weight and its association with IIH [16].This should be done by professionals who manage IIH, or preferably by those that manage obesity.A casual conversation of body weight in the emergency setting may do more harm than good [16].Weight loss methods have evolved over time and the evidence from studies demonstrated good correlation between weight loss and disease remission, however sustained weight loss has not generally been achievable through dietary interventions alone [36].
The IIH weight trial (IIHWT) was a United Kingdom (UK) multicenter randomised controlled trial that evaluated the effect of bariatric surgery and a community weight management intervention on intracranial pressure in women with active IIH and a body mass index of 35 kg/m 2 or greater [37].It found that bariatric surgery provided sustained ICP reduction and weight loss for up to two years of follow-up.A health economic analysis was undertaken and this showed by five years, bariatric surgery was more cost-effective than a dietary weight management programme [38].A per protocol analysis of this trial helped determine how much weight should be lost to ensure disease remission, as defined by normalisation of ICP measured by a lumbar puncture.This was found to be 24% of body weight [39].This magnitude of weight loss is likely only to be achieved with bariatric surgery [36].The IIHWT was successful in its primary outcome, however there was no statistical improvement in visual fields.This was likely as it was a cohort of patients with a long duration of the disease [40].It should also be noted that 24% weight reduction may not be required for remission of papilloedema, where others have found weight reduction of between 5-15% beneficial [41].A systematic review of weight loss in IIH may be a useful aide [36].
While metabolic and bariatric surgery will deliver additional health benefits, by reversing life-threatening weight related health problems such as certain cancers, cardiovascular disease, and diabetes [42]; there are many barriers to accessing the weight management pathways [43].In the UK there are various programmes that people with an abnormal BMI potentially may have access to (Table 1): unfortunately, due to supply and demand a number of services may be gapped in certain regions [44].

HOW DO WE TREAT CASE 1 WITH MILD OPTIC NERVE OEDEMA, NORMAL VISUAL FUNCTION AND HEADACHES?
Start by asking permission to talk about body weight.Explain the condition and association of body weight change and IIH.Then recommending weight reduction (5-15% of current weight as discussed above), and agree how that could be achieved.In addition conservative treatment for headaches may be best, the headaches have only been present for 8 weeks and they may settle once the ICP settles.Advice regarding the use of simple analgesics to treat headaches should be given and highlight that taking too many pain killers could lead to medication overuse headache [22].
In Case 1 with mild optic nerve oedema and normal visual function the joint decision was made to start a weight management programme with a nutritionist, increase physical activity and monitor the clinical signs and symptoms.Should the person have an increase of weight, or escalating symptoms, they should be instructed to contact the clinic for advice.

HOW DO WE MONITOR PATIENTS WITH IIH?
As ophthalmologists, we have a crucial role in managing patients with IIH.Detailed evaluation to be sure that visual function is preserved and that papilloedema resolves is paramount.Evaluation at regular intervals should include best corrected visual acuity (BCVA), colour vision, pupillary responses and dilated fundus exam.Optic disc photos are useful for documentation and comparison of fundus appearance over time.Formal perimetry is essential to assess optic nerve function.The use of OCT with measurement of peripapillary retinal nerve fibre layer (pRNFL) thickness; disc volume scanning and a macular ganglion cell protocol [45].The frequency of follow up is determined by the level of optic nerve oedema, optic nerve function, and response to treatment [14].

CASE 1 -OUTCOME
We recommended follow up at 4 weeks, following the first visit.At that time, despite losing 2 kg, visual field and optic nerve appearance had progressed and the patient continued to have headaches.In the IIHWT analysis it was shown that if little or no weight was lost, it could be likely that the disease would progress [39].She was therefore started on treatment with acetazolamide 500 mg twice a day and we planned for follow up in 4 weeks.At follow up her headaches had improved; and the visual field and optic nerve appearance were back to baseline to mildly improved.Given the good response to treatment, we planned for follow up in 3 months.

CASE 2
A 44-year-old African American female with a past medical history of polycystic ovary syndrome (PCOS) and living with obesity (BMI 39 kg/m 2 ) was referred for evaluation for papilloedema.She had prior evaluations for headaches diagnosed as migraines; however, treatment was not helping, her vision was becoming blurry and recently she had developed pulsatile tinnitus.Past ocular history was negative.Her medications included ibuprofen 600 mg and sumatriptan 50 mg for migraines, losartan, and atorvastatin.On examination her BCVA was 6/6 in both eyes, colour vision was intact and both pupils were reactive with no RAPD.Dilated fundus exam revealed bilateral optic nerve oedema with obliteration of the physiologic cup and partial obscuration of the disc vessels (Fig. 2).OCT peripapillary RNFL average thickness measured 249microns OD and 219microns OS (Fig. 2).Humphrey 30-2 perimetry showed generalised depression and blind spot enlargement worse in the right eye (Fig. 3).The brain MRI with and without contrast was unremarkable and brain MRV with contrast demonstrated mild bilateral narrowing of the transverse sinus, no evidence of thrombosis was seen.The patient did not have anaemia.The lumbar puncture opening pressure was 45 cm H 2 O and CSF had normal constituents.

HOW DO WE TREAT CASE 2 WITH MODERATE OPTIC NERVE OEDEMA, ABNORMAL VISUAL FUNCTION AND HEADACHES?
Case 2 had moderate compromise of visual function and more severe optic nerve oedema.Treatment included acetazolamide 500 mg twice a day with planned titration up to 1000 mg twice a day over a week and referral to the local weight management programme.Follow up examination two weeks later showed BCVA at 6/6 both eyes, mildly decreased colour vision in the right eye with right RAPD and worsening visual field more significant in the right eye (Fig. 3).The optic nerve oedema had not changed, as evidenced by her OCT imaging.She reported of persistent pulsatile tinnitus and headaches.She had found it difficult to comply with the acetazolamide due to side effects.Due to worsening visual function, persistent severe optic nerve oedema, intolerance to acetazolamide and weight gain in the preceding months, options of intensive weight management or a surgical option to save the sight was discussed with the patient.Together we decided to proceed with surgical management of IIH.The patient underwent placement of a right frontal ventriculoperitoneal shunt (VPS) without complications.

CASE 2 -OUTCOME
Following VPS placement, ocular examination showed BCVA 6/6 in both eyes, right RAPD, improved visual fields and optic nerve oedema.She continued treatment with a weight management programme and eventually underwent bariatric surgery.PCOS is a recognised disease associated with IIH, living with both conditions makes it challenging to sustainably lose weight [46].The visual and headache outcomes of those with IIH with or without PCOS are similar [47].Those with PCOS may benefit from targeted weight management with endocrinology.Following bariatric surgery her BMI dropped to 20.5 kg/m 2 and she did not have a relapse.Visual function and visual fields have remained stable and she has now been discharged.

SURGICAL MANAGEMENT OF IIH
The decision to proceed to surgical management in medically refractory cases should be made on a case by case basis.In this case the visual function was deteriorating rapidly leaving little room for a trial of furosemide or spironolactone, or a very low calorie diet.The decision to proceed to surgery needs to be made jointly with the patient.The surgical management of IIH includes optic nerve sheath fenestration (ONSF), CSF diversion procedures and venous stenting.In most cases the decision is based on the individual patient, each institution's experience and surgical availability.ONSF is preferred in patients with no significant headache but with severe compromise of vision and persistent optic nerve oedema.It requires an experienced, trained surgeon.
ONSF appears to have less morbidity than CSF diversion procedures.The overall risk of complications is around 10-15%, including a 1-2% risk of loss of vision due to central retinal artery or central retinal vein occlusion (CRAO or CRVO).The most common complications are diplopia, anisocoria and tonic pupil.ONSF does not lower ICP and is not recommended for the treatment of headaches.In some cases, bilateral ONSF is needed to treat papilloedema in the fellow eye [48,49].
CSF diversion procedures, ventriculoperitoneal shunt and lumboperitoneal shunt, reduce ICP efficiently, leading to resolution of optic nerve oedema and improvement of headaches (in the short term).These procedures require skilled neurosurgeons and can have a number of complications: shunt malfunction, infection, dislocation, which may require re-intervention [49].In the UK we encourage the use of an ICP monitor, programmable valve and anti-syphon valve for improved outcomes [34,[50][51][52].
The newest option for treatment is neurovascular stenting [53,54].The role of venous stenting in IIH is not clearly defined yet.It may be useful in selected patients with elevated ICP, with venous stenosis and proven elevated pressure gradient, who have failed or cannot tolerate medical treatment.One of the disadvantages is the need for antiplatelet therapy for 6 months following the treatment [54].There is a UK randomised control trial evaluating the use of stenting in comparison to shunting [55].

CASE 3
A 28-year-old female with a history of essential hypertension and living with obesity (BMI 38 kg/m 2 ) presented complaining of darkening vision, worse in the left eye.She reported 3 weeks of progressively worsening severe headache and diplopia.Over the last week she developed frequent transient visual obscurations in both eyes and pulsatile tinnitus.On examination BCVA was 6/9 in the right eye and 6/60 in the left eye.She was able to identify 10/ 14 Ishihara plates with the right eye and 3/14 with the left eye.Both pupils were sluggish with left RAPD.A right cranial nerve VI palsy was present.Dilated fundus exam revealed severe optic nerve oedema bilaterally (Fig. 4).The global pRNFL thickness was 338microns in the right eye and 334microns in the left eye.Humphrey perimetry 24-2 showed severe generalised depression in both eyes, worse on the left (Fig. 4).
Due to rapidly evolving symptoms of increased ICP and worsening vision over days, along with severe optic nerve oedema, we made the presumptive diagnosis of fulminant IIH.Fulminant IIH is a form of IIH that affects a small percentage of patients [56].These patients have a very aggressive course with acute onset of symptoms and signs of intracranial hypertension with severe visual loss occurring within weeks of the initial diagnosis or at a relapse of symptoms [57].Acute presentation with rapid loss of vision is not common and requires ruling out other causes of loss of vision, such as: malignant hypertension, meningitis, cerebral venous disease, optic neuritis (such as myelin oligodendrocyte glycoprotein antibody-associated disease, neuromyelitis optica spectrum disorder, sarcoidosis, syphilis, etc), and optic nerve infiltration (leukaemia, lymphoma).All of which should be picked up in the investigational pathway.
It is important to understand the aggressive nature of this condition and to act immediately.Patients with fulminant IIH should be admitted for expedited work up and treatment.After we ascertained that blood pressure was normal in case 3, we proceeded with work up and treatment.MRI brain and orbit with and without contrast and MRV with and without contrast revealed bilateral enhancement of the optic nerve head and dilation of the optic nerve sheaths, a partially empty sella and narrowing of the transverse sinuses with no evidence of thrombosis.There was no anaemia and no use of precipitating medications.The lumbar puncture opening pressure was 80 cm H 2 O and CSF had a normal composition.Immediate treatment included placement of a lumbar drain, oral acetazolamide 500 mg three times a day to be titrated up to 3-4 g/day rapidly, and intravenous (IV) methylprednisolone 1 g/day for 3 days.Note treatment with steroids is not recommended in IIH with the exception of fulminant cases where a short course of IV methylprednisolone has been more typically used in North American practice, particularly in paediatric cases [58,59].In the United Kingdom IV methylprednisolone is not typically used in adults with fulminant IIH.Further evidence would be required to understand the mechanism by which glucocorticoids may be beneficial here.
We consulted with an oculoplastic specialist for possible ONSF and with neurosurgery for possible CSF diversion surgery.It can take time to arrange the emergency surgery, due to the rarity of the surgery.After placement of a lumbar drain, ICP decreased to 50 cm H 2 O but BCVA decreased to counting fingers in the left eye, so the patient underwent left ONSF two days after admission.BCVA remained stable in the right eye at 6/6 and improved to 6/20 in the left eye.Colour vision showed persistent compromise bilaterally.The cranial nerve VI palsy and headaches persisted.Due to the ongoing symptoms and signs and excessively raised ICP the patient finally underwent a right VP shunt placement by neurosurgery four days following the initial admission.

CASE 3 -OUTCOME
The final BCVA was 6/6 in the right eye and 6/24 left eye, with decreased colour vision in both eyes.Cranial nerve VI palsy resolved completely and both optic nerves developed atrophy.Humphrey 30-2 perimetry improved but both eyes had severe peripheral contraction.SIGHT THREATENING IIH Thambisetty et al. [58].published a case series of fulminant IIH.In his series all the patients presented with severe loss of visual acuity, had severe papilledema, visual fields were constricted and the first lumbar puncture showed a mean CSF opening pressure of 54.1 cm H 2 O, with a range between 29 and 70 cm H 2 O.All patients were treated surgically due to rapidly worsening vision.Visual function improved in all patients but despite the aggressive treatment, 50% of them remained legally blind and all of them had residual visual field defects and optic nerve atrophy.Hyder et al. [34].published a modern case series of patients with sight threatening disease.They noted the more swollen the optic nerve as measured with the initial pRNFL, the impact on long-term visual outcomes was worse.The HVF baseline mean deviation showed that those with a mean deviation worse than −7 dB, did not recover their vision as compared to those whose baseline mean deviation was better than −7 dB.Headache outcomes improved post-surgery however regressed to baseline within 12 months despite ICP normalisation.There has been recent discussion that the definition of fulminant IIH should not be defined by a time from diagnosis to sight threatening disease, but should be defined as the sight threatening disease.This is to ensure that patients do not inadvertently come to harm by a time based definition [57].

CONCLUSION
IIH is a complex condition with different degrees of compromise of visual function and headaches that can be debilitating [60].In this opinion piece we have not fully discussed weight management [16], headache therapies [20,22], the mental health burden [61] or the maternal health concerns [62]: all of which need to be addressed in a person living with IIH [14,15].We have focused on an article for ophthalmologists, where the eye examination determines management.The more severely compromised the visual function, the faster and more aggressively we need to act.Overall, the investigation and management of IIH is a team effort including ophthalmologists, neurologists, neurosurgeons and weight management experts.More patients with IIH will be attending clinic, as the increase in prevalence and incidence is evident [4,12,63].Fortunately, there is new research in this area, with the potential for targeted therapies [64,65].

SUMMARY
What was known before • Ophthalmologists have a key role in protecting the vision in people who present with papilloedema.
• Incidence and prevalence of Idiopathic Intracranial Hypertension (IIH) is rising.

•
The majority of people living with IIH are also living with obesity; there are many barriers to managing weight loss.

What this review adds
• While IIH is emerging as a metabolic systemic disease that is distinct from obesity, treating obesity can reverse IIH.

Ophthalmologists can provide basic advice to help reduce headache burden.
• There is a lack of high quality evidence to direct which surgical interventions should be recommended in people with sight threatening disease.

Fig. 1
Fig. 1 This figure shows Case 1 with mild papilloedema.A colour fundus image of the left eye; and B right eye.Humphrey 30-2 perimetry showed mild enlargement of the blind spot bilaterally with very mild peripheral changes; C grey scale left eye; and D right eye.

Fig. 2
Fig. 2 This figure shows Case 2 with moderate papilledema that then has worsening of their visual function and in whom acetazolamide is not tolerated.A colour fundus image of the right eye; and B left eye.C the pRNFL print out with a global RNFL of right eye (OD) 259microns and left eye (OS) 249microns.

Fig. 3
Fig. 3 This composite figure shows Case 2 with moderate papilledema that then has worsening of their visual function and in whom acetazolamide is not tolerated.A HVF 30-2 of the left eye at the first visit; and B HVF 30-2 of the right eye at first visit.Both have enlargement of the blind spots, worse on the right.C HVF 30-2 of the left eye at the sight threatening visit; and D HVF 30-2 of the right eye when fulminant sight threatening disease is evident with progression of the superior loss and peripheral field constriction.

Fig. 4
Fig. 4 This is a composite figure of Case 3 with severe papilloedema.A colour fundus image of the left eye; and B right eye.Humphrey 30-2 perimetry showed mild enlargement of the blind spot bilaterally with very mild peripheral changes; C grey scale left eye; and D right eye.

Table 1 .
Programmes for weight management in the United Kingdom (correct at time of publication).are delivered by local community weight management services, that provide community based diet, nutrition, lifestyle and behaviour change advice, normally in a group setting environment.Normally people can only access these services for a limited time period, often only 12 weeks.For example Birmingham City Council have programmes for people with learning disabilities; people who are visually impaired and people who are physically impaired.Online or face to face e.g.
https://www.birmingham.gov.uk/info/50263/supporting_healthier_lives/2480/support_to_manage_weight_tier_2_adult_weight_management_service(last accessed 24th March 2024) Tier 3 weight management services Patients must have a BMI of 40 kg/m 2 or over (or 35 kg/m 2 or over if co-morbidities exist).Patients much have engaged with community weight services over a 2 year period (attendance dates should be provided as evidence) and attended a Tier 2 weight management service unless BMI is 50 kg/m 2 or greater aDepends on region, some stipulate GP referralClinician led multidisciplinary team (MDT) which may consist of a combination of a specialist nurse, specialist dietitian, psychologist, psychiatrist and physiotherapist.In practice these are the specialist weight management clinics that provide non-surgical, intensive medical management