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Genotype guided glaucoma surgery

Eye (2023)Cite this article

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Myocilin gene (MYOC) mutations contribute to 4% of primary open angle glaucoma and >10% of juvenile open angle glaucoma (JOAG) [1]. Aberrant myocilin proteins accumulate in trabecular meshwork (TM) cell endoplasmic reticulum leading to cell death [2, 3]. As the proximal outflow pathway is implicated in myocilin-associated glaucoma, it is cogent to choose treatments targeting the TM. We report the case of a 25-year-old female with autosomal dominant myocilin-associated JOAG treated with ab interno 360-degree trabeculotomy using the OMNI system (Sight Sciences, Menlo Park, CA).

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Fig. 1: Optical coherence tomography and visual fields.
Fig. 2: Photographs from surgical video showing OMNI procedure.

References

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Author notes

  1. These authors contributed equally: Seth Dhillon, Sundeep Deol, Andrew J. Tatham.

Authors and Affiliations

  1. Princess Alexandra Eye Pavilion and Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK

    Seth Dhillon, Sundeep Deol & Andrew J. Tatham

Authors
  1. Seth Dhillon
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  2. Sundeep Deol
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  3. Andrew J. Tatham
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All authors contributed equally to this work.

Corresponding author

Correspondence to Andrew J. Tatham.

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Competing interests

AJT: Speaker (Sight Sciences, Alcon, AbbVie, Thea, Santen), Consultant (Thea, Santen, AbbVie, Roche), Research support (AbbVie, Alcon). Other authors (none).

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Dhillon, S., Deol, S. & Tatham, A.J. Genotype guided glaucoma surgery. Eye (2023). https://doi.org/10.1038/s41433-023-02484-1

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  • DOI: https://doi.org/10.1038/s41433-023-02484-1

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