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Optical coherence tomography angiography measurements in Parkinson’s disease: A systematic review and meta-analysis

Eye volume 37, pages 3145–3156 (2023)Cite this article

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A Correction to this article was published on 15 September 2023

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Abstract

Optical coherence tomography angiography (OCT-A) is an ocular imaging technology that has emerged as a non-invasive tool to evaluate retinal microvascular changes in neurodegenerative diseases including Parkinson’s disease (PD) and Alzheimer’s disease. While several studies have reported on the presence of pathologic retinal microvascular alterations in PD, the utility of OCT-A as a biomarker for PD evaluation is still unclear. A systematic review and meta-analysis were performed to explore the current evidence for the role of OCT-A in PD published up until June 2022. PubMed, Scopus, and Web of Science databases were used to systematically identify relevant papers and a meta-analysis was conducted using Stata16 software according to the level of heterogeneity applying a random- or fixed-effect model. Thirteen studies of 925 eyes in the PD group and 1501 eyes in the control group assessing OCT-A findings in PD patients were included. The meta-analyses revealed that the foveal region of PD patients had a significantly lower vessel density in the superficial capillary plexus (SCP) compared to healthy controls but that there were no significant differences in the foveal avascular zone, the SCP in whole, parafoveal, and perifoveal regions, and deep capillary plexus. OCT-A metrics may act as a potential biomarker for a more accurate and early PD diagnosis. Still, the OCT-A algorithms and interchangeability between OCT-A devices require further standardization to draw clinical conclusions regarding their utility.

摘要 摘要

相干光断层扫描血管成像 (Optical coherence tomography angiography, OCT-A) 是一种非侵入性眼部成像技术, 用于评估帕金森病 (Parkinson’s disease, PD) 和阿尔茨海默病等神经退行性疾病的视网膜微血管变化。虽然有几项研究报道了PD中存在视网膜病理性微血管改变, 但OCT-A用于评估PD的作用尚不清楚。我们进行了系统综述和荟萃分析, 检索了截至2022年6月发表的OCT-A在帕金森病中作用的现有证据。使用PubMed、Scopus和Web of Science数据库系统地检索相关文献, 并使用Stata16软件根据随机或固定效应模型的异质性水平进行meta分析。纳入13项研究, 包括PD组925只眼和对照组1501只眼, 评估PD患者OCT-A发现。荟萃分析显示, 与健康对照组相比, PD患者的中心凹区浅层毛细血管丛 (superficial capillary plexus, SCP) 的血管密度显著降低, 但在中心凹无血管区、整个、中心凹旁和中心凹周围区域的SCP和深层毛细血管丛中无统计学差异。OCT-A在PD早期精确诊断中可能作为一个潜在的生物标志物。但是OCT-A算法和OCT-A设备之间的互换性需要进一步标准化, 以得出关于其临床实用性的结论。

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The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Author notes

  1. These authors contributed equally: Mohammad Amin Salehi, Fateme Rezagholi, Soheil Mohammadi.

Authors and Affiliations

  1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Amin Salehi, Soheil Mohammadi & Mahdi Gouravani

  2. School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

    Fateme Rezagholi

  3. School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Seyed Sina Zakavi

  4. School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

    Ali Jahanshahi

  5. Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, IL, USA

    Ghasem Yazdanpanah

  6. College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA

    Ian Seddon

  7. Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Sayena Jabbehdari

  8. Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

    Rishi P. Singh

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Contributions

Author contributions included conception and study design (SM and MAS), article screening (AJ and MAS and SM), data collection or acquisition (SSZ, MAS, and SM), statistical analysis (MAS and SM), interpretation of results (MAS and SM and FR), drafting the manuscript work or revising it critically for important intellectual content (MAS, SM, FR, MG, GY, IS, SJ, and RS) and approval of the final version to be published and agreement to be accountable for the integrity and accuracy of all aspects of the work (MAS, SM, FR, MG, GY, IS, SJ, and RS).

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Correspondence to Rishi P. Singh.

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Authors declare no conflicts of interest except Dr. Rishi P. Singh who is a consultant for Genentech, Regeneron, Alcon, Bausch and Lomb, Asclepix, Gyroscope, Novartis.

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The original online version of this article was revised:. In the sub-section ‘Density measurements in deep capillary plexus’, the following sentence “Meta-analysis of these three studies also did not reveal any significant changes (MD, −0.61; 95% CI [−1.78 to 0.56]; P-value = 0.30; I² = 0.00)” was corrected to read “Meta-analysis of these two studies (26,40) also did not reveal any significant changes (MD, −0.61; 95% CI [−1.78 to 0.56]; P-value = 0.30; I² = 0.00)”. Additionally, the reference numbers in the tables 1, 2, 3, as well as the supplementary tables s1 and s2 have been corrected.

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Salehi, M.A., Rezagholi, F., Mohammadi, S. et al. Optical coherence tomography angiography measurements in Parkinson’s disease: A systematic review and meta-analysis. Eye 37, 3145–3156 (2023). https://doi.org/10.1038/s41433-023-02483-2

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