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Correlation between AI-measured lacquer cracks extension and development of myopic choroidal neovascularization

Eye volume 37, pages 2963–2968 (2023)Cite this article

Subjects

Abstract

Objectives

To investigate the correlation between the AI-measured area of the lacquer cracks (LC) at their first detection and the occurrence of a choroidal neovascularization (CNV) during the follow-up in patients affected by pathologic myopia. Secondary outcome was the detection of a correlation between the time to onset of CNV with both baseline LC area and LC area increase during follow-up.

Methods

Optical coherence tomography (OCT) acquisitions of patients diagnosed with LC were retrospectively analysed. The study population was divided in a CNV group (showing the documented onset of a CNV) and a n-CNV group (no CNV development during follow-up). LC area was measured using MatLab software after the application of a customized method for LC segmentation on infrared (IR) enface images.

Results

Forty-five (45) patients with a mean follow-up of 4.9 ± 1.5 years were included. LC area at baseline was 2.82 ± 0.54 mm2 and 1.70 ± 0.49 mm2 in CNV (20 patients) and n-CNV group (25 patients) group respectively (p < 0.001). LC area increase was significantly higher in CNV group (p < 0.001). Time to onset of CNV was linearly correlated with both LC area at baseline (p = 0.006) and LC area increase (p < 0.001).

Conclusions

Myopic CNV development is associated with lager LC areas and higher LC area increase during time. Earlier CNV onset is inversely correlated with LC area and LC area increase.

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Fig. 1: LC segmentation process.
Fig. 2: Evolution of LC in a patient from CNV group.
Fig. 3: Enface IR and OCT B scan of a patient who did not develop CNV within follow up period.
Fig. 4: Upper graphs: Linear correlation between time to onset of CNV and LC area (left image) and Δ LC area (right image).

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Data availability

Data supporting the results reported in the article are available upon reasonable request to the Corresponding author.

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Author information

Author notes

  1. These authors contributed equally: Emanuele Crincoli, Silvia Ferrara.

Authors and Affiliations

  1. Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil 40, avenue de Verdun, Créteil, 94100, France

    Emanuele Crincoli, Alexandra Miere & Eric H. Souied

  2. Catholic University of “Sacro Cuore”, Rome, Italy

    Emanuele Crincoli & Silvia Ferrara

  3. Department of Ophthalmology University Vita-Salute IRCCS San Raffaele Scientific Institute, Via Olgettina, 60 20132, Milan, Italy

    Riccardo Sacconi, Marco Battista & Giuseppe Querques

  4. Departement of Ophthalmology, Hopital Fondation Adolphe De Rothschild, 29 Rue Manin, 75019, Paris, France

    Fiammetta Catania

Authors
  1. Emanuele Crincoli
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  7. Eric H. Souied
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  8. Giuseppe Querques
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Contributions

Conceptualization, EC; Methodology, EC, FC; Software, EC, FC; Validation, GQ, EHS; Formal analysis, EC; Investigation, AM, MB, RS, SF; Resources, GQ, RS; Data curation, AM, MB, RS, SF; Writing—original draft preparation, EC, SF; Writing—review and editing, GQ, RS; Supervision, GQ; Project administration, GQ. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Silvia Ferrara.

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Crincoli, E., Ferrara, S., Miere, A. et al. Correlation between AI-measured lacquer cracks extension and development of myopic choroidal neovascularization. Eye 37, 2963–2968 (2023). https://doi.org/10.1038/s41433-023-02451-w

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