The Endophthalmitis Vitrectomy Study sought to evaluate the roles of immediate vitrectomy and systemic antibiotic treatment in the management of post-operative endophthalmitis following cataract surgery or secondary intraocular lens implantation, presenting within 6 weeks of the original surgery (median time to presentation was 6 days). The intervention (either vitrectomy, or vitreous tap) was performed within 6 h of the initial examination. All patients received intravitreal amikacin (0.4 mg) and vancomycin (0.1 mg), in addition to sub-conjunctival and topical antibiotics and steroids, with oral prednisolone (30 mg twice daily for 5–10 days). BCVA – best corrected visual acuity; IOL – intraocular lens; IV – intravenous; ETDRS – Early Treatment Diabetic Retinopathy Study; LP – light perception vision; VA – visual acuity; ns – not statistically significant.
Reference: Endophthalmitis Vitrectomy Study Group. A Randomized Trial of Immediate Vitrectomy and of Intravenous Antibiotics for the Treatment of Postoperative Bacterial Endophthalmitis. Arch Ophthalmol. 1995;113:1479-1496.
Funding
Medical Research Council UK (MR/R000735/1).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
competing interests
The authors declare no competing interests.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Yusuf, I.H., Henein, C. & Sivaprasad, S. Infographic: A randomized trial of immediate vitrectomy and of intravenous antibiotics for postoperative bacterial endophthalmitis: the endophthalmitis vitrectomy study. Eye (2023). https://doi.org/10.1038/s41433-023-02389-z
Received:
Revised:
Accepted:
Published:
DOI: https://doi.org/10.1038/s41433-023-02389-z
