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Structural integrity of retinal pigment epithelial cells in eyes with age-related scattered hypofluorescent spots on late phase indocyanine green angiography (ASHS-LIA)

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Fig. 1: Frequency of ASHS-LIA in our cohort.
Fig. 2: The alternating bright and dark pattern (ASHS-LIA), not evident on optical coherence tomography (OCT), was visible using late phase ICGA in a healthy eye (63-year-old) in both conventional and adaptive optics imaging.

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The authors would like to thank Alfredo Dubra for assistance with adaptive optics instrumentation and software, and Mike Arango, Denise Cunningham, HaeWon Jung, Jianfei Liu, Rongwen Lu, Christina Appleman, Jenny Suy, Sharon Yin, John Rowan, Patrick Lopez, Guy Foster, Gloria Babilonia-Ayukawa, Daniel Claus, and Angel Garced for assistance with study procedures. This work was supported by the Intramural Research Program of the National Institutes of Health, National Eye Institute.

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JL and JT contributed to the design and writing of the letter. JL, NA, and JT contributed to data analysis and discussion. JL, NA, TL, AJB, JPG, and JT contributed to data collection. CC, TK, EC, BPB, WMZ, LAH, and RBH contributed to patient referral and clinical examination. All authors reviewed the final draft.

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Correspondence to Johnny Tam.

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Li, J., Aguilera, N., Liu, T. et al. Structural integrity of retinal pigment epithelial cells in eyes with age-related scattered hypofluorescent spots on late phase indocyanine green angiography (ASHS-LIA). Eye 37, 377–378 (2023).

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