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Childhood visual impairment and blindness: 5-year data from a tertiary low vision center in Israel



To assess the main causes leading to childhood visual impairment/blindness in a center for low vision in Israel and to analyze the literature on pediatric blinding diseases in developed countries.


Retrospective study based on observational case series. Data were obtained from medical records of visually impaired children, seen at a national referral low vision center. Children were divided into two groups: moderate visual impairment (6/18 to 6/60) and severe visual impairment (SVI)/blindness (<6/60). Inherited eye diseases (IED) were grouped together for analysis. Data from the Israeli blind registry from the same period of time were analyzed for comparison. A review of literature on childhood blindness in developed countries since 2000 was conducted.


A total of 1393 children aged 0–18 years were included in the study. Moderate visual impairment was seen in 1025 (73.6%) and SVI/blindness in 368 (26.4%) of the studied children. Among blind children, IED accounted for at least 51% of all diagnoses, including mainly albinism and retinal dystrophies. IED prevalence was equally high in both main ethnic groups (Jewish and Arab Muslims). Non-IED (22.6%) included mainly patients with cerebral visual impairment and retinopathy of prematurity.


The leading cause of childhood visual impairment and blindness in our patient cohort was IED. Analyses of the literature from the last two decades show that IED are a major cause for SVI/childhood blindness in other developed countries as well. Updated patterns of global childhood blindness may suggest a need for new approach for screening programs and modern tactics for prevention.

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  1. Frick KD, Foster A. The magnitude and cost of global blindness: an increasing problem that can be alleviated. Am J Ophthalmol. 2003;135:471–6.

    Article  Google Scholar 

  2. Kalua K, Patel D. Causes of blindness among children identified through village key informants in Malawi. Can J Opthalmol. 2008;43:425–7.

  3. Gogate P, Kalua K, Courtright P. Blindness in childhood in developing countries: time for a reassessment? PLoS Med. 2009;6:e1000177.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Solebo AL, Rahi J, Teoh L. Epidemiology of blindness in children. Arch Dis Child. 2017;102:853–7.

  5. World Health Organization. Programme for the Prevention of Blindness and Deafness. Global initiative for the elimination of avoidable blindness. World Health Organization. 2000.

  6. Khan RI, O’Keefe M, Kenny D, Nolan L. Changing pattern of childhood blindness. Ir Med J. 2007;100:458–61.

    CAS  PubMed  Google Scholar 

  7. Farber MD. National Registry for the Blind in Israel: estimation of prevalence and incidence rates and causes of blindness. Ophthalmic Epidemiol. 2003;10:267–77.

    Article  PubMed  Google Scholar 

  8. Mezer E, Chetrit A, Kalter-Leibovici O, Kinori M, Ben-Zion I, Wygnanski-Jaffe T. Trends in the incidence and causes of severe visual impairment and blindness in children from Israel. J Am Assoc Pediatr Ophthalmol Strabismus. 2015;19:260–265.e1.

    Article  Google Scholar 

  9. Durnian JM, Cheeseman R, Kumar A, Raja V, Newman W, Chandna A. Childhood sight impairment: a 10-year picture. Eye. 2010;24:112–7.

    CAS  Article  PubMed  Google Scholar 

  10. Gilbert C, Rahi J, Eckstein M, O’Sullivan J, Foster A. Retinopathy of prematurity in middle-income countries. Lancet. 1997;350:12–4.

    CAS  Article  PubMed  Google Scholar 

  11. Rahi JS, Cable N, British Childhood Visual Impairment Study Group. Severe visual impairment and blindness in children in the UK. Lancet. 2003:1359–465.

  12. Rosenberg T, Flage T, Hansen E, Riise R, Rudanko SL, Viggosson G, et al. Incidence of registered visual impairment in the Nordic child population. Br J Ophthalmol. 1996;80:49–53.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  13. de Verdier K, Ulla E, Löfgren S, Fernell E. Children with blindness—major causes, developmental outcomes and implications for habilitation and educational support: a two-decade, Swedish population-based study. Acta Ophthalmol. 2018;96:295–300.

    Article  PubMed  Google Scholar 

  14. Bosch DG, Boonstra FN, de Leeuw N, Pfundt R, Nillesen WM, de Ligt J, et al. Novel genetic causes for cerebral visual impairment. Eur J Hum Genet. 2016;24:660–5.

    CAS  Article  Google Scholar 

  15. Rudanko SLLL. Visual impairment in children born at full term from 1972 through 1989 in Finland. Opthalmology. 2004;111:2307–12.

  16. Kong L, Fry M, Al-Samarraie M, Gilbert C, Steinkuller PG. An update on progress and the changing epidemiology of causes of childhood blindness worldwide. J Am Assoc Pediatr Ophthalmol Strabismus. 2012;16:501–7.

    Article  Google Scholar 

  17. Boonstra N, Limburg H, Tijmes N, van Genderen M, Schuil J, van Nispen R. Changes in causes of low vision between 1988 and 2009 in a Dutch population of children. Acta Ophthalmol. 2012;90:277–86.

    Article  PubMed  Google Scholar 

  18. Yahalom C, Macarov M, Lazer-Derbeko G, Altarescu G, Imbar T, Hyman JH, et al. Preimplantation genetic diagnosis as a strategy to prevent having a child born with an heritable eye disease. Ophthalmic Genet. 2018.

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The authors thank the Israeli National Registry for the Blind and the Ministry of Welfare in Israel for providing access to the national data on childhood blindness.

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CY was responsible for designing the research protocol, analysis and interpretation of data, writing and revising the manuscript. RB, RP, and IS were responsible for collecting and analyzing the data, searching for references, and revising the manuscript. MM and AB were involved in data acquisition, analysis, interpretation and drafting the manuscript. KH was responsible for analysis and interpretation of data, writing and revising the manuscript. All of the authors gave final approval of this version to be published.

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Correspondence to Claudia Yahalom.

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The authors declare no competing interests.

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Yahalom, C., Braun, R., Patal, R. et al. Childhood visual impairment and blindness: 5-year data from a tertiary low vision center in Israel. Eye (2021).

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