Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Photoreceptor outer segment layer contributes to optical coherence tomography signal attenuation beneath neurosensory detachments

Abstract

Purpose

To establish the factors responsible for attenuation of the optical coherence tomography (OCT) signal beneath the neurosensory detachment (NSD).

Methods

We retrospectively reviewed 33 eyes with acute central serous chorioretinopathy. The thickness of the neurosensory retina, the thickness of the photoreceptor outer segment (PROS) layer, the height of the NSD, and the reflectivity of the underlying retinal pigment epithelium (RPE) were measured at selected points of B-scans exported from 6 × 6 mm OCT angiography protocols. The intensity of the flow signal was measured at the corresponding regions of the choriocapillaris slab. The correlation between the parameters of the NSD and both the reflectivity of underlying RPE and the intensity of the flow signal in the choriocapillaris was calculated.

Results

Correlation coefficients between RPE reflectivity and neurosensory retinal thickness, PROS layer thickness, and NSD height were −0.32, −0.64, and −0.25, respectively (p < 0.001). Correlation coefficients between the intensity of the flow signal and neurosensory retinal thickness, PROS layer thickness, and NSD height were −0.24 (p = 0.004), −0.52 (p < 0.001), and 0.13 (p = 0.13), respectively.

Conclusion

The thickness of the PROS layer is the most significant factor affecting OCT signal at the level of RPE and OCT angiography flow signal in the choriocapillaris beneath the NSD.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Optical coherence tomography B-scan showing evaluation of the parameters of neurosensory detachment and the reflectivity of underlying retinal pigment epithelium.
Fig. 2: Optical coherence tomography B-scan showing evaluation of the parameters of neurosensory detachment and the flow signal intensity in the optical coherence tomography angiography projection of the choriocapillaris slab.
Fig. 3: Scatter plots showing correlation between photoreceptor outer segment layer thickness and variables under study.
Fig. 4: Optical coherence tomography angiography projection of the choriocapillaris slab showing a visible increase of the flow signal (arrowhead) corresponding to a thinning of photoreceptor outer segment layer (arrow) and an area of increased reflectivity of the retinal pigment epithelium (asterisk).

References

  1. 1.

    Wang Q, Chan S, Yang JY, You B, Wang YX, Jonas JB, et al. Vascular density in retina and choriocapillaris as measured by optical coherence tomography angiography. Am J Ophthalmol. 2016;168:95–109.

    Article  Google Scholar 

  2. 2.

    Lumbroso B, Rispoli M, Savastano MC. Longitudinal optical coherence tomography–angiography study of type 2 naive choroidal neovascularization early response after treatment. Retina. 2015;35:2242–51.

    CAS  Article  Google Scholar 

  3. 3.

    de Carlo TE, Bonini Filho MA, Chin AT, Adhi M, Ferrara D, Baumal CR, et al. Spectral-domain optical coherence tomography angiography of choroidal neovascularization. Ophthalmology 2015;122:1228–38.

    Article  Google Scholar 

  4. 4.

    Kayat KV, Roisman L, Zett C, Novais EA, Farah ME. Choriocapillaris hypoperfusion artifact in OCT angiography. Ophthalmic Surg Lasers Imaging Retin. 2018;49:603–10.

    Article  Google Scholar 

  5. 5.

    van den Berg TJ, Spekreijse H. Near infrared light absorption in the human eye media. Vis Res. 1997;37:249–53.

    Article  Google Scholar 

  6. 6.

    Asano KS, Asaoka R, Asano S, Azuma K, Inoue T, Obata R. Elongated photoreceptor outer segment length and prognosis of chronic central serous chorioretinopathy. Retin. 2020;40:750–7.

    CAS  Article  Google Scholar 

  7. 7.

    Maltsev DS, Kulikov AN, Chhablani J. Topography-guided identification of leakage point in central serous chorioretinopathy: a base for fluorescein angiography-free focal laser photocoagulation. Br J Ophthalmol. 2018;102:1218–25.

    Article  Google Scholar 

  8. 8.

    Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, et al. Central serous chorioretinopathy: recent findings and new physiopathology hypothesis. Prog Retinal Eye Res. 2015;48:82–118.

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Dmitrii S. Maltsev.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Maltsev, D.S., Kulikov, A.N. & Kazak, A.A. Photoreceptor outer segment layer contributes to optical coherence tomography signal attenuation beneath neurosensory detachments. Eye (2021). https://doi.org/10.1038/s41433-021-01736-2

Download citation

Search

Quick links