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Localized versus 360° intraoperative laser retinopexy in cases of rhegmatogenous retinal detachment with mild-to-moderate grade proliferative vitreoretinopathy



To compare the efficacy of intraoperative localized and 360° laser retinopexy in cases of rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy and air tamponade.


In this interventional, prospective, randomized, comparative study, 93 consecutive cases of RRD were enroled. After randomization 48 eyes received circumferential, while 45 underwent localized intraoperative laser retinopexy. Number and position of the retinal breaks, presence of proliferative vitreoretinopathy and/or lattice degeneration were recorded. Anatomical and visual outcome of the two groups were compared at 6 months postoperatively.


Baseline characteristics did not significantly differ between groups. The single-operation reattachment rate was 86.66% in localized group and 89.58% in 360° group. The difference was not significant. (P = 0.46, χ2 test). At 6 months postoperatively, visual acuity (logMAR) was 0.06 ± 0.05 in localized group and 0.05 ± 0.03 in 360° group. The difference was not statistically significant (P= 0.673, t-test).


Localized laser resulted to be as effective as 360° laser application; this may lead some advantages in term of lower invasiveness, reduction risk of complications and time saving.

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  1. 1.

    Schwartz SG, Flynn HW Jr., Mieler WF. Update on retinal detachment surgery. Curr Opin Ophthalmol. 2013;24:255–61.

    Article  Google Scholar 

  2. 2.

    Hwang JC. Regional practice patterns for retinal detachment repair in the United States. Am J Ophthalmol. 2012;153:1125–8.

    Article  Google Scholar 

  3. 3.

    Folk JC, Sneed SR, Folberg R, Coonan P, Pulido JS. Early retinal adhesion from laser photocoagulation. Ophthalmology. 1989;96:1523–5.

    CAS  Article  Google Scholar 

  4. 4.

    Pollack A, Milstein A, Oliver M, Zalish M. Circumferential argon laser photocoagulation for prevention of retinal detachment. Eye. 1994;8:419–22.

    Article  Google Scholar 

  5. 5.

    Machemer R, Aaberg TM, Freeman HM, Irvine AR, Lean JS, Michels RM. An updated classification of retinal detachment with proliferative vitreoretinopathy. Am J Ophthalmol. 1991;112:159–65.

    CAS  Article  Google Scholar 

  6. 6.

    Jaccoma EH, Conway BP, Campochiaro PA. Cryotherapy causes extensive breakdown of the blood-retinal barrier. A comparison with argon laser photocoagulation. Arch Ophthalmol. 1985;103:1728–30.

    CAS  Article  Google Scholar 

  7. 7.

    Yoon YH, Marmor MF. Rapid enhancement of retinal adhesion by laser photocoagulation. Ophthalmology. 1988;95:1385–8.

    CAS  Article  Google Scholar 

  8. 8.

    Campochiaro PA, Kaden IH, Vidaurri-Leal J, Glaser BM. Cryotherapy enhances intravitreal dispersion of viable retinal pigment epithelial cells. Arch Ophthalmol. 1985;103:434–6.

    CAS  Article  Google Scholar 

  9. 9.

    Pastor JC, de la Rua ER, Martin F. Proliferative vitreoretinopathy: risk factors and pathobiology. Prog Retin Eye Res. 2002;21:127–44.

    Article  Google Scholar 

  10. 10.

    Azar G, Wolff B, Cornut PL, Mauget-Faysse M. Serous retinal detachment following panretinal photocoagulation (PRP) using Pattern Scan Laser (PASCAL) photocoagulator. GMS Ophthalmol Cases. 2012;2:Doc01.

    PubMed  PubMed Central  Google Scholar 

  11. 11.

    Zhou C, Zheng Z, Qiu Q. Pars plana vitrectomy with 360 degrees versus localized laser retinopexy in the management of retinal detachment with undetected breaks intraoperatively: a retrospective, comparative, interventional study. Lasers Med Sci. 2017;32:583–9.

    Article  Google Scholar 

  12. 12.

    Avitabile T, Longo A, Lentini G, Reibaldi A. Retinal detachment after silicone oil removal is prevented by 360 degrees laser treatment. Br J Ophthalmol. 2008;92:1479–82.

    CAS  Article  Google Scholar 

  13. 13.

    Laidlaw DA, Karia N, Bunce C, Aylward GW, Gregor ZJ. Is prophylactic 360-degree laser retinopexy protective? Risk factors for retinal redetachment after removal of silicone oil. Ophthalmology. 2002;109:153–8.

    Article  Google Scholar 

  14. 14.

    Koh HJ, Cheng L, Kosobucki B, Freeman WR. Prophylactic intraoperative 360 degrees laser retinopexy for prevention of retinal detachment. Retina. 2007;27:744–9.

    Article  Google Scholar 

  15. 15.

    Iwase T, Jo Y-J, Oveson BC. Effect of prophylactic 360° laser treatment for prevention of retinal detachment after phacovitrectomy: (prophylactic 360° laser treatment for prevention of retinal detachment). BMC Ophthalmol. 2013;13:77.

    Article  Google Scholar 

  16. 16.

    Bilgin AB, Dogan ME, Aysun B, Apaydin KC. Pars plana vitrectomy with or without intraoperative 360 degrees peripheral endolaser for rhegmatogenous retinal detachment treatment. Int Ophthalmol. 2019;39:1687–94.

    Article  Google Scholar 

  17. 17.

    Thompson JT. Kinetics of intraocular gases. Disappearance of air, sulfur hexafluoride, and perfluoropropane after pars plana vitrectomy. Arch Ophthalmol. 1989;107:687–91.

    CAS  Article  Google Scholar 

  18. 18.

    Tetsumoto A, Imai H, Hayashida M, Otsuka K, Matsumiya W, Miki A, et al. The comparison of the surgical outcome of 27-gauge pars plana vitrectomy for primary rhegmatogenous retinal detachment between air and SF6 gas tamponade. Eye. 2019.

  19. 19.

    Wiedemann P. Growth factors in retinal diseases: proliferative vitreoretinopathy, proliferative diabetic retinopathy, and retinal degeneration. Surv Ophthalmol. 1992;36:373–84.

    CAS  Article  Google Scholar 

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Correspondence to Pasquale Loiudice.

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Loiudice, P., Montesel, A., Sartini, F. et al. Localized versus 360° intraoperative laser retinopexy in cases of rhegmatogenous retinal detachment with mild-to-moderate grade proliferative vitreoretinopathy. Eye 35, 786–790 (2021).

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