Repeatability and reliability of measurements obtained by the combined Scheimpflug and Placido-disk tomography in different stages of keratoconus

Abstract

Objective

The objective of this study is to evaluate the repeatability and reliability of corneal parameters in different stages of keratoconus patients using a combined Scheimpflug–Placido disc analysis system.

Materials and methods

In this prospective study, three consecutive measurements were performed by the same observer using Scheimpflug–Placido disc anterior segment analysis device in keratoconus patients. Flattest and steepest simulated keratometry and corneal volume, corneal aberrations, thinnest corneal thickness, symmetry index, keratoconus vertex and Baiocchi–Calossi–Versaci index were recorded. Keratoconic eyes were divided into four stages using the Amsler–Krumeich classification. Repeatability was evaluated using within the subject standard deviation, repeatability index (Ri) and coefficient of variation; reliability was evaluated by intraclass correlation coefficient (ICC). Pearson correlation coefficients were used to assess the correlation between the parameters evaluated.

Results

Two hundred sixty-one eyes of 261 keratoconus patients were included in the study. The repeatability for all corneal curvature parameters decreased as the keratoconus severity increased, and there is a positive correlation between keratometry of the apex and corneal curvature parameters (p < 0.05) except mean simulated keratometry. The corneal aberrations were repeatable in all keratoconus subgroups (Ri < 0.34 μm). There are also positive correlations between keratometry of apex and corneal aberrations (p < 0.05) except total high-order root mean square and spherical aberration. The reliability was excellent (ICC > 0.90) for all indices except keratoconus vertex back.

Conclusion

The parameters used in the diagnosis and follow-up of keratoconus in the Sirius corneal tomography system may differ more than expected at stages 3 and 4 of the disease. Awareness of this situation may be helpful in planning follow-up and treatment.

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Acknowledgements

Thanks to Sibel Donmez (SD) for performing Sirius tomography.

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Correspondence to Yusuf Yıldırım.

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Tunç, U., Akbaş, Y.B., Yıldırım, Y. et al. Repeatability and reliability of measurements obtained by the combined Scheimpflug and Placido-disk tomography in different stages of keratoconus. Eye (2020). https://doi.org/10.1038/s41433-020-01238-7

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