Table 3 Prognostic factors for local recurrence, regional lymph node metastasis, and tumour-related death

From: Eyelid sebaceous carcinoma: Validation of the 8th edition of the American Joint Committee on cancer T staging system and the prognostic factors for local recurrence, nodal metastasis, and survival

 Local recurrenceRegional lymph node metastasisTumour-related death
Hazard ratio (95% CI)p-valueHazard ratio (95% CI)p-valueHazard ratio (95% CI)p-value
Age > 50 (years)0.49 (0.11–2.11)0.3350.42 (0.13–1.35)0.2320.23 (0.02–2.49)0.227
Gender (male)1.01 (0.35–2.9)0.9852.07 (0.72–5.99)0.1790.74 (0.08–7.05)0.797
Histopathology
 Tumour dimension > 20 mm1.08 (0.3–3.89)0.9023.07 (1.02–9.21)0.0452.66 (0.23–31.03)0.435
 Perineural invasion3.85 (1.06–13.97)0.041.11 (0.14–8.46)0.92319.63 (2.66–144.71)0.003
 Perivascular invasion8.18 (2.37–28.3)0.0011.6 (0.36–7.21)0.5385.06 (0.46–55.94)0.186
 Lymphatic invasion5.23 (1.59–17.26)0.0071.3 (0.29–5.88)0.734.22 (0.38–47.05)0.241
 Basaloid differentiation3.62 (1.23–10.6)0.0191.21 (0.42–3.5)0.72610.68 (0.82–138.94)0.07
 Squamoid differentiation1.03 (0.29–3.69)0.9650.64 (0.14–2.89)0.5666.84 (0.62–75.67)0.117
 Pagetoid spread5.47 (1.6–18.72)0.0071.55 (0.54–4.44)0.4143.07 (0.35–27.16)0.313
 Section margin free0.12 (0.03–0.44)0.0010.23 (0.07–0.72)0.012Not availablea 
Tumour involvement
 Both eyelids4.71 (1.63–13.62)0.0041.63 (0.51–5.21)0.4097.82 (0.7–87.13)0.095
 Paranasal sinus4.85 (1.35–17.41)0.0165.09 (1.39–18.56)0.01417.5 (1.55–197.38)0.021
 Intracranium11.26 (2.79–45.34)0.0013.33 (0.74–14.96)0.117Not availablea 
 Orbit3.84 (1.33–11.08)0.0163.31 (1.1–9.95)0.0338.43 (0.77–92.04)0.08
 Orbital wall1.93 (0.27–13.58)0.5082.66 (0.34–20.51)0.3480.75 (0.01–37.94)0.886
  1. aNumber of events is too small to perform Cox regression analyses