We have read the recent article from Agorogiannis et al.  reporting real world data from the treatment of polypoidal choroidal vasculopathy (PCV) in a Caucasian cohort with great interest. As described, there is a paucity of data from Caucasian individuals to inform the management of PCV, and so we aim to augment their informative dataset with longer follow-up and a greater representation of verteporfin photodynamic therapy (PDT) (Table 1).
Mean (SD) gain in ETDRS letters at one, two, three and four years was 0.8 (17.2), −1.6 (21.7), −1.6 (24.1) and −8.5 (29.7), respectively. Central foveal thickness (CFT) also improved at those timepoints by 68.0 µm (204.9), 96.7 µm (124.9), 83.5 µm (153.2) and 128.6 µm (142.6). Although the mean acuity gained from PDT monotherapy was greater than from the combination of PDT and anti-vascular endothelial growth factor (anti-VEGF) treatment at each timepoint, improvement in CFT was consistently poorer. However, neither of these differences were statistically significant. Nine of the 14 participants receiving combination treatment started with PDT and so the subsequent addition of anti-VEGF likely reflected refractory disease, thereby biasing inter-group comparisons. This bias is demonstrated by Fig. 1 where more dramatic visual decline is experienced by combination treatment recipients.
PDT monotherapy led to significantly fewer treatment episodes than combination therapy at every timepoint (P < 0.01 from 6 to 36 months). At 3 years the mean (SD) number of treatment episodes with PDT was 1.8 (1.0) compared to 9.0 (4.4) for combination treatment.
The present series demonstrates visual stability up to 48 months and mean acuity gains (6.3 ETDRS letters at 12 months) from PDT monotherapy comparable to combination treatment outcomes in clinical trials and anti-VEGF monotherapy reported by Agorogiannis et al. (n = 24) [1, 2]. It also emphasises the significantly lower treatment burden experienced by patients in the real world setting if the addition of anti-VEGF is not required. These retrospective data must be balanced against the superior visual outcomes from combination treatment in randomised clinical trials in Asian populations . However, with considered case selection and monitoring, we also feel that PDT monotherapy remains a valuable initial treatment option to minimise treatment burden in PCV .
Agorogiannis EI, Pearce IA, Yadav S, Parry DG, Beare NAV. Clinical outcomes in Caucasian patients with polypoidal choroidal vasculopathy. Eye. 2018; 32:1731–9.
Cheung CMG, Lai TYY, Ruamviboonsuk P, Chen S-J, Chen Y, Freund KB, et al. Polypoidal choroidal vasculopathy: definition, pathogenesis, diagnosis, and management. Ophthalmology. 2018;125:708–24.
Conflict of interest
JH: Unrelated travel grant from Bayer. SJT: Bayer—advisory board, travel support, research support; Novartis—advisory board research support; Roche—Research support. None of these relates to this work directly.
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Approval for maintenance and analysis of this pseudonymised retrospective dataset was sought from the local Caldicott guardian.
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Hogg, H.D.J., Talks, S.J. Comment on: Clinical outcomes in Caucasian patients with polypoidal choroidal vasculopathy. Eye 33, 1190–1191 (2019). https://doi.org/10.1038/s41433-019-0387-1