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The effectiveness of autologous platelet-rich concentrates as an adjunct during nonsurgical periodontal therapy: a systematic review and meta-analysis of randomized controlled trials

Evidence-Based Dentistry (2024)Cite this article

Subjects

Abstract

Objectives

To evaluate the efficacy of autologous platelet concentrates (APC) on periodontal outcomes in nonsurgical therapy of periodontitis patients.

Method

Electronic search via Web of Science, MEDLINE via PubMed, Scopus, and Cochrane CENTRAL registry as well as manual search were done from June 2024 to July 2024 for relevant publication from inception until June 2024. The articles were assessed by 2 independent reviewers and deemed relevant when the interventional studies reported on periodontal outcomes after adjunctive APC were used in NSPT. The studies were excluded if it was not in English or unpublished. The risk of bias for each study was assessed using the Cochrane risk-of-bias tool (RoB 2). Fixed effect meta-analysis was conducted to measure the summary effect for change of periodontal pocket depth (PPD) and Clinical Attachment Level (CAL). The statistical heterogeneity between studies was also calculated using I2 test.

Result

A total of 607 records were found in the four electronic databases. Following the removal of duplicates and initial title screening, 16 full text articles from electronic search and 7 articles from manual search were assessed resulting in 13 studies included in the systematic review. The overall risk of bias showed most studies have moderate to high risk of bias. The fixed-effect meta-analysis showed summary effects favored the adjunctive use of APC in nonsurgical periodontal therapy but with high heterogeneity between the studies, particularly for CAL.

Conclusion

The evidence on APC as adjunct in NSPT is limited by the small number of studies, moderate to high risk of bias in most studies and significant heterogeneity in the results.

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Fig. 1: Study search and selection from databases and other methods.
Fig. 2: Mean Difference of PPD between intervention and control groups.
Fig. 3: Mean Difference of CAL between intervention and control groups.

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Data availability

The data and research materials such as template data collection forms; data extracted from included studies; data used for all analyses; analytic code; any other materials used in the review that support the findings of this study are available on request from the corresponding author (NNE).

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Periodontology Centre of Studies, Faculty of Dentistry, Universiti Teknologi MARA, Jalan Hospital, 47000, Sungai Buloh, Malaysia

    Nazurah Nik Eezammuddeen, Nurina Nasuha Johari & Olevia Demius

  2. Faculty of Dentistry, MAHSA University, Jalan SP 2, Bandar Saujana Putra, 42610, Jenjarom, Malaysia

    Fouad Hussain Al-bayaty

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  1. Nazurah Nik Eezammuddeen
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All authors equally contributed to the completion of the systematic review and writing of the manuscript.

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Correspondence to Nazurah Nik Eezammuddeen.

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Nik Eezammuddeen, N., Johari, N.N., Demius, O. et al. The effectiveness of autologous platelet-rich concentrates as an adjunct during nonsurgical periodontal therapy: a systematic review and meta-analysis of randomized controlled trials. Evid Based Dent (2024). https://doi.org/10.1038/s41432-024-01060-0

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