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Microsatellite instability in gastrointestinal cancers

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References

  1. Velho S, Corso G, Oliveíra C, Seruca R. KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers. Adv Cancer Res. 2010;109:123–43.

    CAS  Article  Google Scholar 

  2. Leite M, Corso G, Sousa S, Milanezi F, Afonso LP, Henrique R, et al. MSI phenotype and MMR alterations in familial and sporadic gastric cancer. Int J Cancer. 2011;128:1606–13.

    CAS  Article  Google Scholar 

  3. Corso G, Pedrazzani C, Marrelli D, Pascale V, Pinto E, Roviello F. Correlation of microsatellite instability at multiple loci with long-term survival in advanced gastric carcinoma. Arch Surg. 2009;144:722–7.

    CAS  Article  Google Scholar 

  4. Corso G, Pascale V, Flauti G, Ferrara F, Marrelli D, Roviello F. Oncogenic mutations and microsatellite instability phenotype predict specific anatomical subsite in colorectal cancer patients. Eur J Hum Genet. 2013;21:1383–8.

    CAS  Article  Google Scholar 

  5. Berardinelli GN, Durães R, Mafra da Costa A, Bragagnoli A, Antônio de Oliveira M, Pereira R, et al. Association of microsatellite instability (MSI) status with the 5-year outcome and genetic ancestry in a large Brazilian cohort of colorectal cancer. Eur J Hum Genet. 2022. in press

  6. Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, et al. Microsatellite instability is associated with the presence of lynch syndrome pan-cancer. J Clin Oncol. 2019;37:286–95.

    CAS  Article  Google Scholar 

  7. Pedrazzani C, Corso G, Velho S, Leite M, Pascale V, Bettarini F, et al. Evidence of tumor microsatellite instability in gastric cancer with familial aggregation. Fam Cancer. 2009;8:215–20.

    CAS  Article  Google Scholar 

  8. Diaz LA Jr., Shiu KK, Kim TW, Jensen BV, Jensen LH, Punt C, et al. Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study. Lancet Oncol. 2022;23:659–70.

    Article  Google Scholar 

  9. Muro K, Chung HC, Shankaran V, Geva R, Catenacci D, Gupta S, et al. Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial. Lancet Oncol. 2016;17:717–26.

    CAS  Article  Google Scholar 

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Acknowledgements

The preparation of this study was partially supported by the Italian Ministry of Health with Ricerca Corrente and 5 ×1000 funds.

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Correspondence to Giovanni Corso.

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Corso, G. Microsatellite instability in gastrointestinal cancers. Eur J Hum Genet (2022). https://doi.org/10.1038/s41431-022-01134-6

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  • DOI: https://doi.org/10.1038/s41431-022-01134-6

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