Correction to: European Journal of Human Genetics https://doi.org/10.1038/s41431-020-00748-y, published online 31 October 2020

Corrigendum for de Graaf G, Buckley F, Skotko BG. Estimation of the number of people with Down syndrome in Europe. European Journal of Human Genetics. 29(3):402-410.

In our modeling of population prevalence for Down syndrome (DS), we unintentionally used an estimation based on applying survival rates from Model D (developed for the former East bloc) for Greece. The Figures in the Supplementary Materials for Greece are correct (model A was applied, which was developed for the non-former East bloc); however, in the main article the wrong DS population number for Greece was reported. This impacted the estimations for the population numbers for Southern Europe, non-former West bloc countries, and Europe as a total.

In the main article, we had reported that our model estimated 417,000 people with DS living in Europe as of 2015, and without elective terminations 572,000; this should be (using the right number for Greece) 419,000 and 574,000 instead. DS population prevalence was reported at 5.6 per 10,000; this should be 5.7 per 10,000. Population reduction rate is unchanged.

The percentage of people with DS under the age of 20 in Southern Europe was estimated at 24%; this should be 23%.

Reduction of population prevalence as a result of DS-related terminations was estimated at 33% in Southern Europe; this should be 32%.

The number of people with DS in Greece (Table 1 in the main article) was estimated at 5146, and in Southern Europe at 96,075. This should be 7035, and 97,964 instead.

Figure 3 in the main paper should be adapted for Greece, Southern Europe, Europe without former East bloc, and Europe total. In the Table below, the corrections are presented in red:

Table 1
Full size table

Changes in Fig. 4 regarding Southern Europe are very small; the corrected Figure for Southern Europe can be found in the Supplement, page 257.