Taste perception and lifestyle: insights from phenotype and genome data among Africans and Asians

Abstract

Taste is essential for the interaction of animals with their food and has co-evolved with diet. Humans have peopled a large range of environments and present a wide range of diets, but little is known about the diversity and evolution of human taste perception. We measured taste recognition thresholds across populations differing in lifestyles (hunter gatherers and farmers from Central Africa, nomad herders, and farmers from Central Asia). We also generated genome-wide genotype data and performed association studies and selection scans in order to link the phenotypic variation in taste sensitivity with genetic variation. We found that hunter gatherers have lower overall sensitivity as well as lower sensitivity to quinine and fructose than their farming neighbors. In parallel, there is strong population divergence in genes associated with tongue morphogenesis and genes involved in the transduction pathway of taste signals in the African populations. We find signals of recent selection in bitter taste-receptor genes for all four populations. Enrichment analysis on association scans for the various tastes confirmed already documented associations and revealed novel GO terms that are good candidates for being involved in taste perception. Our framework permitted us to gain insight into the genetic basis of taste sensitivity variation across populations and lifestyles.

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Fig. 1: Differences in taste perception among populations.
Fig. 2: FST values between populations.

Data availability

Data are freely available for download after request at http://jakobssonlab.iob.uu.se/data/ and at EMBL-EBI web site: http://www.ebi.ac.uk/arrayexpress/arrays/A-MTAB-679 and http://www.ebi.ac.uk/arrayexpress/arrays/A-MTAB-678.

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Acknowledgements

We would like to thank all the volunteer participants that gave their time to contribute to this study. We would like the IRD Yaoundé for providing precious material help on the field in Cameroon, and the Bukhara Hospital for agreeing on hosting the experiment in Uzbekistan.

Funding

This work was supported by the Danone-FRM prize for nutrition and lifestyle, the ANR Growing-App, the CNRS bilateral collaborative projects PICS “Tracing past demography in Central Asian Human populations from genetic data—An Uzbek-French collaboration” and “Statistical methods that can scale with the dimension of the genomic data,” and the Swedish Research Council. AS has been financed by a Ph.D. grant from the Pierre et Marie Curie University of Paris VI and by a Swedish Research Council Grant to MJ.

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Contributions

AES, MJ, EH, and MGB conceived and designed the study. AES, EH, TH, AN, and FS performed data sampling. AES and PS performed the analysis. AES, EH, MJ, MGB, and PS wrote the paper. All authors read and approved the final paper.

Corresponding authors

Correspondence to Michael G. B. Blum or Evelyne Heyer or Mattias Jakobsson.

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The authors declare that they have no conflict of interest.

Ethical approval

The research has been performed following authorization obtained from an agreement between the Immunogen Lab, the Academy of Sciences of Uzbekistan, and the Centre National de la Recherche Scientifique (CNRS) and Muséum National d’Histoire Naturelle (MNHN) in France. The research was approved by the Comite de protection des personnes—Ill de France 1, Paris, France, under the dossier numbers: DC-2009-1068 and 2010-avril-12276.

Informed consent

For Cameroon, written and audio-recorded informed consent was obtained from all participants for the collected phenotypic and genetic data. The research has been performed according to an agreement between the IRD, the Cameroonese Ministry of Research, the Université Yaoundé 1, the Catholic university and the Douala University according to the French Cameroonese scientific collaboration agreement of 1984 ORSTOM. For Uzbekistan, participants gave written informed consent for the collected phenotypic and genetic data.

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Sjöstrand, A.E., Sjödin, P., Hegay, T. et al. Taste perception and lifestyle: insights from phenotype and genome data among Africans and Asians. Eur J Hum Genet (2020). https://doi.org/10.1038/s41431-020-00736-2

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