Imputation of behavioral candidate gene repeat variants in 486,551 publicly-available UK Biobank individuals

Abstract

Some of the most widely studied variants in psychiatric genetics include variable number tandem repeat variants (VNTRs) in SLC6A3, DRD4, SLC6A4, and MAOA. While initial findings suggested large effects, their importance with respect to psychiatric phenotypes is the subject of much debate with broadly conflicting results. Despite broad interest, these loci remain absent from the largest available samples, such as the UK Biobank, limiting researchers’ ability to test these contentious hypotheses rigorously in large samples. Here, using two independent reference datasets, we report out-of-sample imputation accuracy estimates of >0.96 for all four VNTR variants and one modifying SNP, depending on the reference and target dataset. We describe the imputation procedures of these candidate variants in 486,551 UK Biobank individuals, and have made the imputed variant data available to UK Biobank researchers. This resource, provided to the scientific community, will allow the most rigorous tests to-date of the roles of these variants in behavioral and psychiatric phenotypes.

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Acknowledgements

We thank the participants of the FTP, CADD/GADD and UK Biobank studies. This work was supported by NIH R01MH100141 to MCK and the Institute for Behavioral Genetics. RB is supported by NIH T32MH016880. The FTP was supported by NICHD HD064687. CADD was supported by NIDA DA011015 and DA035804. GADD was supported by DA012845, DA035804, and DA021692. This work utilized the RMACC Summit supercomputer, which is supported by the National Science Foundation (awards ACI-1532235 and ACI-1532236), the University of Colorado Boulder, and Colorado State University.

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Correspondence to Luke M. Evans.

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BIORXIV PREPRINT: https://doi.org/10.1101/358267

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