To investigate the effects of rapeseed oil on body composition, blood glucose and lipid metabolism in people with overweight and obesity compared to other cooking oils. We searched eight databases for randomized controlled studies (including randomized crossover trials). The risk of bias for the included studies was assessed using the Cochrane Risk of Bias 2.0 tool. The Grading of Recommendations Assessment Development and Evaluation (GRADE) criteria were used to evaluate the quality of the outcomes. The methodological quality of the included studies was assessed using the Physiotherapy Evidence Database (PEDro) scale. Sensitivity analysis was used to check the stability of the pooled results. Statistical analysis was carried out using Review Manager 5.3 software. As a result, fifteen randomized controlled studies (including six parallel studies and nine crossover studies) were included in this study. Compared to other edible oils, rapeseed oil significantly reduced low density lipoprotein cholesterol (LDL-C) (MD = −0.14 mmol/L, 95% CI: −0.21, −0.08, I2 = 0%, P < 0.0001), apolipoprotein B (ApoB) (MD = −0.03 g/L, 95% CI: −0.05, −0.01, I2 = 0%, P = 0.0003), ApoB/ApoA1 (MD = −0.02, 95% CI: −0.04, −0.00, I2 = 0%, P = 0.02) and insulin (MD = −12.45 pmol/L, 95% CI: −19.61, −5.29, I2 = 37%, P = 0.0007) levels, and increased fasting glucose (MD = 0.16 mmol/L, 95% CI: 0.05, 0.27, I2 = 27%, P = 0.003) levels. However, the differences in body weight and body composition between rapeseed oil and control oils were not significant. In a word, rapeseed oil is effective in reducing LDL-C, ApoB and ApoB/ApoA1 levels in people with overweight and obesity, which is helpful in preventing and reducing the risk of atherosclerosis. PROSPERO registration number: CRD42022333436.
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This study was supported by the National Natural Science Foundation of China [grant numbers 82060420] and the Natural Science Foundation of Jiangxi Province, China [grant numbers 20212BAB206004]. The funders had no role in study design, data collection or analysis, preparation of the manuscript, or the decision to publish. The contents of this publication are solely the responsibility of authors and do not necessarily represent the official views of the funding sources.
The authors declare no competing interests.
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Yang, JM., Long, Y., Ye, H. et al. Effects of rapeseed oil on body composition and glucolipid metabolism in people with obesity and overweight: a systematic review and meta-analysis. Eur J Clin Nutr (2023). https://doi.org/10.1038/s41430-023-01344-1