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Translating the advanced glycation end products (AGEs) knowledge into real-world nutrition strategies

European Journal of Clinical Nutrition volume 76, pages 922–928 (2022)Cite this article

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Abstract

Advanced glycation end products (AGEs) are glycated proteins or lipids derived from complex metabolic pathways involved in the pathophysiology of various diseases, especially diabetes and diabetes-related complications. These compounds are omnipresent in human life, with both endogenous and exogenous sources. Despite the well-elucidated disease mechanisms, little is known about the AGEs/nutrition nexus in the circles of clinical practice recommendations. This review seeks to translate the accumulated knowledge about the biochemistry and pathophysiology of AGEs into a nutritional intervention based on real-world prescriptions.

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Fig. 1: It is normal to have some formation of AGEs via the aldose reductase pathway, but this pathway is ten times increased in poorly controlled diabetes and linked to a raised generation of ROS during the conversion of sorbitol to fructose [20].
Fig. 2

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Authors and Affiliations

  1. School of Medicine, Uberlandia Federal University (UFU), Uberlândia, Minas Gerais, Brazil

    Heitor O. Santos

  2. Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, MG, Brazil

    Nilson Penha-Silva

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  1. Heitor O. Santos
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  2. Nilson Penha-Silva
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The authors’ responsibilities were as follows—HOS: review design, full text screening, and manuscript writing. NPS: review of the entire manuscript. All authors read and approved the final manuscript.

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Correspondence to Heitor O. Santos.

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Santos, H.O., Penha-Silva, N. Translating the advanced glycation end products (AGEs) knowledge into real-world nutrition strategies. Eur J Clin Nutr 76, 922–928 (2022). https://doi.org/10.1038/s41430-021-01028-8

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  • DOI: https://doi.org/10.1038/s41430-021-01028-8

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