A 74-year-old female subject with suboptimal management of episodic tension headache was treated with a daily dose of 1.5 g l-arginine and 1.2 g aged garlic extract (AGE). The aim of the intervention was to promote vasodilation of parenchymal cerebral blood vessels. Within 6 weeks of commencing treatment, her self-reported symptoms improved markedly and were sustained at 2 years following commencement. We propose that the putative beneficial effect of l-arginine and AGE in this patient is because of the well-established systemic vasodilatory effects of l-arginine and aged garlic extract. On the hypothesis that migraine is precipitated by cerebral microvascular constriction, we recommend a double-blind randomised controlled trial to clinically test this hypothesis in migraine patients.
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Prisant LM, Gujral JS, Mulloy AL. Hyperthyroidism: a secondary cause of isolated systolic hypertension. J Clin Hypertension. 2006;8:596–9.
Friedman DI, Rausch EA. Headache diagnoses in patients with treated idiopathic intracranial hypertension. Neurology 2002;58:1551–3.
Demet MM, Özmen B, Deveci A, Boyvada S, Adıgüzel H, Aydemir Ö. Depression and anxiety in hyperthyroidism. Arch Med Res. 2002;33:552–6.
Chaliha DR, Vaccarezza M, Takechi R, Lam V, Visser E, Drummond P, et al. A paradoxical vasodilatory nutraceutical intervention for prevention and attenuation of migraine-a hypothetical review. Nutrients. 2020;12:2487.
Rubanyi GM, Johns A, Kauser K. Effect of estrogen on endothelial function and angiogenesis. Vasc Pharmacol. 2002;38:89–98.
MacGregor E. Oestrogen and attacks of migraine with and without aura. Lancet Neurol. 2004;3:354–61.
Weiss N, Ide N, Abahji T, Nill L, Keller C, Hoffmann U. Aged garlic extract improves homocysteine-induced endothelial dysfunction in macro-and microcirculation. J Nutr. 2006;136:750S–4S.
Zeb I, Ahmadi N, Kadakia J, Larijani VN, Flores F, Li D, et al. Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: a randomized clinical trial. J Cardiovasc Dis Res. 2012;3:185–90.
Bode-Böger SM, Muke J, Surdacki A, Brabant G, Böger RH, Frölich JC. Oral l-arginine improves endothelial function in healthy individuals older than 70 years. Vasc Med. 2003;8:77–81.
Rahman K, Billington D. Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J Nutr. 2000;130:2662–5.
The authors would like to thank the patient for their co-operation.
The authors declare no competing interests.
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Chaliha, D., Vaccarezza, M., Lam, V. et al. Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation. Eur J Clin Nutr (2021). https://doi.org/10.1038/s41430-021-00962-x