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Bioactive lipids and vascular disease

European Journal of Clinical Nutrition volume 75, pages 1528–1531 (2021)Cite this article

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Peripheral arterial (vascular) disease (PAD/PVD) (also known as arteriosclerosis obliterans) causes insufficient tissue perfusion that may be compounded by either emboli or thrombi. The disease typically is segmental, with significant variation from patient to patient. PAD occurs in the lower extremities more frequently than in the upper extremities. The primary factor for developing PAD is atherosclerosis and is often associated with other conditions that include coronary artery disease/coronary heart disease (CAD/CHD), atrial fibrillation, cerebrovascular disease, and renal disease.

Often, atherosclerosis is because of hyperlipidemia, diabetes mellitus, hypertension, obesity, hyperhomocysteinemia and smoking. In these conditions, plasma, and tissue concentrations of γ-linolenic acid (GLA), dihomo-GLA (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) in the phospholipid fraction are low which are thought to be protective against the development of these diseases both in experimental animals and humans [1,2,3,4,5,6,7,8,9].

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  1. UND Life Sciences, Battle Ground, WA, USA

    Undurti N. Das

  2. International Research Centre, Biotechnologies of the Third Millennium, ITMO University, Saint-Petersburg, Russia

    Undurti N. Das

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Das, U.N. Bioactive lipids and vascular disease. Eur J Clin Nutr 75, 1528–1531 (2021). https://doi.org/10.1038/s41430-021-00925-2

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