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Nutrition in acute and chronic diseases

Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

European Journal of Clinical Nutrition volume 75, pages 1645–1653 (2021)Cite this article

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A Correction to this article was published on 12 May 2022

This article has been updated

Abstract

Objectives

Arterial stiffness (AS), one of the complications of diabetes, associated with many metabolic factors. This study aimed to investigate the association between 25-hydroxyvitamin D(25(OH)D) and AS in type 2 diabetes mellitus (T2DM).

Methods

We identified 1335 diabetic patients from the Department of Endocrinology, Shanghai Tenth People’s Hospital. Finally, 603 T2DM patients were included in the study. They were divided into two groups: AS group (baPWV ≥ 15,500 cm/s) and the control group (baPWV < 1550 cm/s).

Results

(1) Heart rate (HR) and systolic pressure (SBP) were higher while body weight and body mass index (BMI) were smaller in AS group than the control group (all P < 0.05). (2) Compared to patients without AS, patients with AS showed lower 25(OH)D and higher rate of 25(OH)D deficiency (42 ± 16 vs. 45 ± 17 mol/l, 68% vs. 64%, all P < 0.05). (3) BaPWV was negatively associated with 25(OH)D (r = −0.12, P = 0.004), while positively associated with age, duration of diabetes, HR, SBP, and low-density lipoprotein cholesterol and negatively associated with body weight and BMI (all P < 0.05). (4) Multiple linear regression showed that 25(OH)D was the negatively influencing factor of baPWV (β = −2.2, P = 0.01). Logistic regression showed that age and SBP were risk factor of AS (OR:1.07, 95% CI: 1.05–1.10, P < 0.001; OR:1.03, 95% CI: 1.02–1.04, P < 0.001) while 25(OH)D was protective factor of AS (OR:0.987, 95% CI: 0.976–0.998, P = 0.024).

Conclusions

T2DM patients with AS had lower 25(OH)D and higher rate of 25(OH)D deficiency. There was a negative relationship between 25(OH)D and AS assessed by baPWV.

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Fig. 1: Subject selection process.
Fig. 2: 25(OH)D deficiency and diabetes-related complications in T2DM with and without AS.
Fig. 3: 25(OH)D in T2DM with and without AS.

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Acknowledgements

The authors gratefully acknowledge the financial support from National Key R&D Program of China (Nos. 2018YFC1314100, 2016YFC1305600) and Shanghai Municipality: Shanghai Outstanding Academic Leaders Plan (049).

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

    Bingwei Ma & Shen Qu

  2. Department of Gastrointestinal Surgery, Tongji University School of Medicine, Shanghai Tenth People’s Hospital Affiliated to Tongji University, Shanghai, China

    Bingwei Ma

  3. Chengdu Second People’s Hospital, Chengdu, Sichuan Province, China

    Yao Chen

  4. Thyroid Research Center of Shanghai, Shanghai, China

    Chunjun Sheng, Peng Yang, Xingchun Wang & Shen Qu

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Ma, B., Chen, Y., Sheng, C. et al. Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus. Eur J Clin Nutr 75, 1645–1653 (2021). https://doi.org/10.1038/s41430-021-00870-0

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