Subscribe to Journal
Get full journal access for 1 year
only $41.58 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Wretlind A. Development of fat emulsions. J Parenter Enter Nutr. 1981;5:230–5.
Dudrick SJ, Vars HM, Rawnsley HM, Rhoads JE. Total intravenous feeding and growth in puppies. Fed Proc. 1964;25:481 and further.
Wilmore DW, Dudrick SJ. Growth and development of an infant receiving all nutrients exclusively by vein. J Am Med Assoc. 1968;203:860–4.
Fischer JE, Baldessarini RJ. False neurotransmitters and hepatic failure. Lancet. 1971;2:75–80.
Fischer JE, Rosen HM, Ebeid AM, James JH, Keane JM, Soeters PB. The effect of normalization of plasma amino acids on hepatic encephalopathy in man. Surgery. 1976;80:77–91.
Soeters PB, Ebeid AM, Fischer JE. Review of 404 patients with gastrointestinal fistulas. Impact of parenteral nutrition. Ann Surg. 1979;190:189–202.
Soeters PB, Fischer JE, Franklin C. One hundred and nineteen patients with gastrointestinal fistulas. Arch Chir Neerl. 1977;29:19–31.
Soeters PB, Weir G, Ebeid AM, Fischer JE. Insulin, glucagon, portal systemic shunting, and hepatic failure in the dog. J Surg Res. 1977;23:183–8.
Soeters PB, Fischer JE. Insulin, glucagon, aminoacid imbalance, and hepatic encephalopathy. Lancet. 1976;2:880–2.
Soeters PB. Hepatic encephalopathy, a new perspective for treatment (Ph.D. Thesis). The Netherlands: Maastricht University; 1979.
Soeters PB. Gastro-intestinal fistulas: the role of nutritional support. Acta Chir Belg. 1985;85:155–62.
Rinsema W, Gouma DJ, von Meyenfeldt MF, van der Linden CJ, Soeters PB. Primary conservative management of external small-bowel fistulas. Changing composition of fistula series? Acta Chir Scand. 1990;156:457–62.
Soeters PB, van Leeuwen PA. Ammonia and glutamine metabolism of the intestine. The effect of lactulose and neomycin. Infusionsther Klin Ernahr. 1986;13:186–90.
van Leeuwen PA, van Berlo CL, Soeters PB. New mode of action for lactulose. Lancet. 1988;1:55–6.
Windmueller HG, Spaeth AE. Uptake and metabolism of plasma glutamine by the small intestine. J Biol Chem. 1974;249:5070–9.
Weber JM, Klein S, Wolfe RR. Role of the glucose cycle in control of net glucose flux in exercising humans. J Appl Physiol. 1990;68:1815–9.
van Berlo CL, van Leeuwen PA, Soeters PB. Porcine intestinal ammonia liberation. Influence of food intake, lactulose and neomycin treatment. J Hepatol. 1988;7:250–7.
van Berlo CL, van de Bogaard AE, van der Heijden MA, van Eijk HM, Janssen MA, Bost MC, et al. Is increased ammonia liberation after bleeding in the digestive tract the consequence of complete absence of isoleucine in hemoglobin? A study in pigs. Hepatology. 1989;10:315–23.
Deutz NE, Ten Have GA, Soeters PB, Moughan PJ. Increased intestinal amino-acid retention from the addition of carbohydrates to a meal. Clin Nutr. 1995;14:354–64.
Deutz NE, Reijven PL, Bost MC, van Berlo CL, Soeters PB. Modification of the effects of blood on amino acid metabolism by intravenous isoleucine. Gastroenterology. 1991;101:1613–20.
Soeters PB, de Jong CH, Deutz NE. The protein sparing function of the gut and the quality of food protein. Clin Nutr. 2001;20:97–9.
Deutz NE, Bruins MJ, Soeters PB. Infusion of soy and casein protein meals affects interorgan amino acid metabolism and urea kinetics differently in pigs. J Nutr. 1998;128:2435–45.
Luiking YC, Deutz NE, Jakel M, Soeters PB. Casein and soy protein meals differentially affect whole-body and splanchnic protein metabolism in healthy humans. J Nutr. 2005;135:1080–7.
Boirie Y, Gachon P, Beaufrere B. Splanchnic and whole-body leucine kinetics in young and elderly men. Am J Clin Nutr. 1997;65:489–95.
Boirie Y, Dangin M, Gachon P, Vasson MP, Maubois JL, Beaufrere B. Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci USA. 1997;94:14930–5.
Moore DR, Soeters PB. The biological value of protein. Nestle Nutr Inst Workshop Ser. 2015;82:39–51.
Olde Damink SW, Dejong CH, Deutz NE, Redhead DN, Hayes PC, Soeters PB, et al. Kidney plays a major role in ammonia homeostasis after portasystemic shunting in patients with cirrhosis. Am J Physiol Gastrointest Liver Physiol. 2006;291:G189–94.
Olde Damink SW, Deutz NE, Dejong CH, Soeters PB, Jalan R. Interorgan ammonia metabolism in liver failure. Neurochem Int. 2002;41:177–88.
Olde Damink SW, Jalan R, Redhead DN, Hayes PC, Deutz NE, Soeters PB. Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS. Hepatology. 2002;36:1163–71.
Bruins MJ, Deutz NE, Soeters PB. Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis. Clin Sci. 2003;104:127–41.
Bruins MJ, Koelfat KKV, Soeters PB. The molecular nutrition of amino acids and proteins. Chapter 13: amino acids, protein and the gastrointestinal tract. Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo: Elsevier, Academic Press; 2016.
Deutz NEPRPLM, Athanasas G, Soeters PB. Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs. Clin Sci. 1992;83:607–14.
Soeters PB, Grimble RF. The conditional role of inflammation in pregnancy and cancer. Clin Nutr. 2013;32:460–5.
van der Hulst RR, van Kreel BK, von Meyenfeldt MF, Brummer RJ, Arends JW, Deutz NE, et al. Glutamine and the preservation of gut integrity. Lancet. 1993;341:1363–5.
Hulsewe KW, van der Hulst RR, Ramsay G, van Berlo CL, Deutz NE, Soeters PB. Pulmonary glutamine production: effects of sepsis and pulmonary infiltrates. Intensive Care Med. 2003;29:1833–6.
Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med. 2013;368:1489–97.
Soeters P, Bozzetti F, Cynober L, Elia M, Shenkin A, Sobotka L. Meta-analysis is not enough: the critical role of pathophysiology in determining optimal care in clinical nutrition. Clin Nutr. 2016;35:748–57.
Soeters PB. Rationale for albumin infusions. Curr Opin Clin Nutr Metab Care. 2009;12:258–64.
Jamjittrong S, Matsuda A, Matsumoto S, Kamonvarapitak T, Sakurazawa N, Kawano Y, et al. Postoperative non-steroidal anti-inflammatory drugs and anastomotic leakage after gastrointestinal anastomoses: systematic review and meta-analysis. Ann Gastroenterol Surg. 2020;4:64–75.
Felig P, Owen OE, Wahren J, Cahill GF Jr. Amino acid metabolism during prolonged starvation. J Clin Invest. 1969;48:584–94.
Clowes GH, Jr. Hirsch E, George BC, Bigatello LM, Mazuski JE, Villee CA Jr. Survival from sepsis. The significance of altered protein metabolism regulated by proteolysis inducing factor, the circulating cleavage product of interleukin-1. Ann Surg. 1985;202:446–58.
van der Hulst RR, von Meyenfeldt MF, Deutz NE, Soeters PB. Glutamine extraction by the gut is reduced in depleted [corrected] patients with gastrointestinal cancer. Ann Surg. 1997;225:112–21.
Holm E, Hagmuller E, Staedt U, Schlickeiser G, Gunther HJ, Leweling H, et al. Substrate balances across colonic carcinomas in humans. Cancer Res. 1995;55:1373–8.
Hagmüller E, Kollmar HB, Günther H-J, Holm E, Trede M. Protein metabolism in human colon carcinomas: in vivo investigations using a modified tracer technique with L-[1-13C]Leucine. Cancer Res. 1995;55:1160–7.
Chiolero RL, Revelly JP, Leverve X, Gersbach P, Cayeux MC, Berger MM, et al. Effects of cardiogenic shock on lactate and glucose metabolism after heart surgery. Crit Care Med. 2000;28:3784–91.
Revelly J-P, Tappy L, Martinez A, Bollmann M, Cayeux M-C, Berger MM, et al. Lactate and glucose metabolism in severe sepsis and cardiogenic shock. Crit Care Med. 2005;33:2235–40. https://doi.org/10.1097/01.CCM.0000181525.99295.8F.
Baird GD, van der Walt JG, Bergman EN. Whole-body metabolism of glucose and lactate in productive sheep and cows. Br J Nutr. 1983;50:249–65.
Crocker DE, Ortiz RM, Houser DS, Webb PM, Costa DP. Hormone and metabolite changes associated with extended breeding fasts in male northern elephant seals (Mirounga angustirostris). Comp Biochem Physiol A Mol Integr Physiol. 2012;161:388–94.
Crawford SO, Ambrose MS, Hoogeveen RC, Brancati FL, Ballantyne CM, Young JH. Association of lactate with blood pressure before and after rapid weight loss. Am J Hypertens. 2008;21:1337–42.
Crawford SO, Hoogeveen RC, Brancati FL, Astor BC, Ballantyne CM, Schmidt MI, et al. Association of blood lactate with type 2 diabetes: the atherosclerosis risk in communities carotid MRI study. Int J Epidemiol. 2010;39:1647–55.
Pinto J, Barros AS, Domingues MRM, Goodfellow BJ, Galhano E, Pita C, et al. Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine. J Proteome Res. 2015;14:1263–74.
Reijven PLM, Soeters PB. Vitamin D: A magic bullet or a myth? Clin Nutr. 2020; https://doi.org/10.1016/j.clnu.2019.12.028.
Von Meyenfeldt MF, Meijerink WJ, Rouflart MM, Builmaassen MT, Soeters PB. Perioperative nutritional support: a randomised clinical trial. Clin Nutr. 1992;11:180–6.
Vente JP, Soeters PB, von Meyenfeldt MF, Rouflart MM, van der Linden CJ, Gouma DJ. Prospective randomized double-blind trial of branched chain amino acid enriched versus standard parenteral nutrition solutions in traumatized and septic patients. World J Surg. 1991;15:128–32.
Gouma DJ, von Meyenfeldt MF, Rouflart M, Soeters PB. Preoperative total parenteral nutrition (TPN) in severe Crohn’s disease. Surgery. 1988;103:648–52.
Soeters PB. Plasma albumin: a confusing nutritional measure. Nutrition. 1990;6:267.
Soeters PB, Von Meyenfeldt MF, WJHJ Meijerink, EWHM Fredrix, EFM Wouters, AMWJ Schols, et al. Serum albumin and mortality. Lancet. 1990;335:348–51.
Soeters PB, Wolfe RR, Shenkin A. Hypoalbuminemia: pathogenesis and clinical significance. J Parenter Enter Nutr. 2019;43:181–93.
Visschers RG, Olde Damink SW, Winkens B, Soeters PB, van Gemert WG. Treatment strategies in 135 consecutive patients with enterocutaneous fistulas. World J Surg. 2008;32:445–53.
Visschers RG, Olde Damink SW, Gehlen JM, Winkens B, Soeters PB, van Gemert WG. Treatment of hypertriglyceridemia in patients receiving parenteral nutrition. J Parenter Enter Nutr. 2011;35:610–5.
Visschers RG, van Gemert WG, Winkens B, Soeters PB, Olde Damink SW. Guided treatment improves outcome of patients with enterocutaneous fistulas. World J Surg. 2012;36:2341–8.
Visschers RGJ, Luyer MD, Schaap FG, Olde Damink SWM, Soeters PB. The gut-liver axis. Curr Opin Clin Nutr Metab Care. 2013;16:576–81. https://doi.org/10.1097/MCO.0b013e32836410a4.
Visschers RGJ, Olde Damink SWM, Schreurs M, Winkens B, Soeters PB, van Gemert WG. Development of hypertriglyceridemia in patients with enterocutaneous fistulas. Clin Nutr. 2009;28:313–7.
Visschers RG, Olde Damink SW, van Bekkum M, Winkens B, Soeters PB, van Gemert WG. Health-related quality of life in patients treated for enterocutaneous fistula. Br J Surg. 2008;95:1280–6.
de Jong PC, Wesdorp RI, Volovics A, Roufflart M, Greep JM, Soeters PB. The value of objective measurements to select patients who are malnourished. Clin Nutr. 1985;4:61–6.
Schols AM, Mostert R, Soeters PB, Greve LH, Wouters EF. Nutritional state and exercise performance in patients with chronic obstructive lung disease. Thorax. 1989;44:937–41.
Schols AM, Soeters PB, Dingemans AM, Mostert R, Frantzen PJ, Wouters EF. Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation. Am Rev Respir Dis. 1993;147:1151–6.
Schols AM, Soeters PB, Mostert R, Pluymers RJ, Wouters EF. Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-controlled randomized trial. Am J Respir Crit Care Med. 1995;152:1268–74.
Soeters PB, Reijven PL, van Bokhorst-de van der Schuerenan der MA, Schols JM, Halfens RJ, Meijers JM. et al. A rational approach to nutritional assessment. Clin Nutr.2008;27:706–16.
Cederholm T, Barazzoni R, Austin P, Ballmer P, Biolo G, Bischoff SC, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017;36:49–64.
Jensen GL, Cederholm T, Correia M, Gonzalez MC, Fukushima R, Higashiguchi T, et al. GLIM criteria for the diagnosis of malnutrition: a consensus report from the global clinical nutrition community. J Parenter Enteral Nutr. 2019;43:32–40.
Welters CF, Heineman E, Thunnissen FB, van den Bogaard AE, Soeters PB, Baeten CG. Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis. Dis Colon Rectum. 2002;45:621–7.
Rinsema W, Gouma DJ, von Meyenfeldt MF, Soeters PB. Reinfusion of secretions from high-output proximal stomas or fistulas. Surg Gynecol Obstet. 1988;167:372–6.
Adam JA, Menheere PP, van Dielen FM, Soeters PB, Buurman WA, Greve JW. Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat Metab Disord. 2002;26:274–6.
van Dielen FM, Soeters PB, de Brauw LM, Greve JW. Laparoscopic adjustable gastric banding versus open vertical banded gastroplasty: a prospective randomized trial. Obes Surg. 2005;15:1292–8.
van Gemert W, Greve J, Soeters P. Long-term results of vertical banded gastroplasty: Marlex versus Dacron Banding. Obes Surg. 1997;7:128–35.
van Gemert WG, Adang EM, Greve JW, Soeters PB. Quality of life assessment of morbidly obese patients: effect of weight-reducing surgery. Am J Clin Nutr. 1998;67:197–201.
van Gemert WG, Adang EM, Kop M, Vos G, Greve JW, Soeters PB. A prospective cost-effectiveness analysis of vertical banded gastroplasty for the treatment of morbid obesity. Obes Surg. 1999;9:484–91.
van Gemert WG, Westerterp KR, van Acker BA, Wagenmakers AJ, Halliday D, Greve JM, et al. Energy, substrate and protein metabolism in morbid obesity before, during and after massive weight loss. Int J Obes Relat Metab Disord. 2000;24:711–8.
Baeten CG, Konsten J, Spaans F, Visser R, Habets AM, Bourgeois IM, et al. Dynamic graciloplasty for treatment of faecal incontinence. Lancet. 1991;338:1163–5.
Soeters PB, de Zoete JP, Dejong CH, Williams NS, Baeten CG. Colorectal surgery and anastomotic leakage. Dig Surg. 2002;19:150–5.
van der Hagen SJ, Baeten CG, Soeters PB, Russel MG, Beets-Tan RG, van Gemert WG. Anti-TNF-alpha (infliximab) used as induction treatment in case of active proctitis in a multistep strategy followed by definitive surgery of complex anal fistulas in Crohn’s disease: a preliminary report. Dis Colon Rectum. 2005;48:758–67.
van der Hagen SJ, Soeters PB, Baeten CG, van Gemert WG. Conservative treatment of patients with faecal soiling. Tech Coloproctol. 2011;15:291–5.
van der Hagen SJ, van Gemert WG, Soeters PB, de Wet H, Baeten CG. Transvaginal posterior colporrhaphy combined with laparoscopic ventral mesh rectopexy for isolated Grade III rectocele: a prospective study of 27 patients. Colorectal Dis. 2012;14:1398–402.
Baeten CG, Geerdes BP, Adang EM, Heineman E, Konsten J, Engel GL, et al. Anal dynamic graciloplasty in the treatment of intractable fecal incontinence. N Engl J Med. 1995;332:1600–5.
I first want to acknowledge the contribution of my parents, who never disputed my decisions or the protracted course between leaving secondary school and becoming a licensed surgeon. They inspired me with confidence in myself. Fate has been benevolent to me offering a large number of accidental successive opportunities, without which my career could not have evolved in the way it did. Its backside was that my family had to put up with a father and husband, very often with his head in the clouds of patient care and of why reacts the body the way it does? My first actions in the surgical disciplines must have appeared adequate, so that my boss in the first small Amsterdam hospital, the late Henk van der Reijden pushed me into a training position in surgery in a larger hospital. One of the bosses in that hospital, the late Co Greep was appointed professor of surgery and one of the seven founders of the new medical faculty in Maastricht in 1974 and took with him three surgical residents, including me and one just licensed surgeon. A decade earlier, he had completed a 3-year training residency in Harvard University in Boston, USA during the Vietnam war, because the Massachusetts General Hospital was short in surgical residents that had to enlist in active military service in Vietnam in view of the numerous casualties of American soldiers. He therefore had easy access to the surgeons in Boston allowing us to be introduced and become clinical fellows in surgery and research, even receiving modest salaries. In Maastricht, there was no previous academic activity, so that everything proposed was welcome and money was available. Simultaneously, Foppe ten Hoor, a biologist and nutritionist was attracted as head of the department of Human Biology in the Biosciences part of the faculty. He realized that collaboration with the clinical departments would boost activities in this field. This started a fruitful collaboration, later leading to NUTRIM, the School of Nutrition and Translational Research in Metabolism. In the paper, I mentioned a number of names that have been important in the development of the field and my career. I want to add the nurses and dietitians in the nutrition team (Margriet Rouflart, Esther van den Hoogen), technicians in the laboratory (Hans van Eyk, Mieke Janssen), and colleagues (Maarten von Meyenfeldt, Jan Willem Greve, Wim van Gemert, René van der Hulst, Kees Dejong, Steven Olde Damink) and PhD students, some of which devised new studies following evolving themes deepening insight in metabolism in specific disease states. The collaboration with the department of Human Biology (Klaas Westerterp, Wim Saris) allowed to develop and use advanced techniques (body composition, tracer methodology, energy metabolism) that greatly facilitated and improved our research, for which I am grateful.
Conflict of Interest
The author declares that he has no conflict of interest.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Soeters, P.B. A serendipitous voyage in the field of nutrition and metabolism in health and disease: a translational adventure. Eur J Clin Nutr 74, 1375–1388 (2020). https://doi.org/10.1038/s41430-020-0584-9