Table 3 Effect of probiotics on serum inflammatory factors, chemokines, and intestinal barrier function.

From: Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury

  NC PC LP HP Between-group comparisons
P1 P2
IL-1β, pg/ml 27.56 ± 6.08 40.17 ± 6.66* 37.27 ± 5.61 36.09 ± 8.41 0.000 0.008
TNF-α, pg/ml 52.91 ± 12.39 103.09 ± 15.39* 101.40 ± 10.15* 98.44 ± 11.43* 0.000 0.041
IL-6, pg/ml 38.67 ± 9.39 208.6 ± 78.31* 203.99 ± 30.77* 141.6 ± 28.60* 0.000 0.000
IL-10, pg/ml 102.04 ± 27.60 82.29 ± 21.46 97.04 ± 32.80 155.63 ± 36.92* 0.000 0.000
RANTES, ng/ml 19.47 ± 6.47 52.56 ± 7.37* 49.35 ± 5.38* 45.82 ± 10.81* 0.000 0.043
MCP-1, pg/ml 77.19 ± 9.15 115.99 ± 20.93* 100.30 ± 10.20 93.13 ± 14.10 0.000 0.001
D-lactates, μg/ml 0.77 ± 0.17 1.48 ± 0.15* 1.37 ± 0.23* 1.24 ± 0.13* 0.000 0.000
Endotoxin, EU/ml 0.03 ± 0.02 0.24 ± 0.01* 0.17 ± 0.01 0.11 ± 0.02 0.000 0.000
I-FABP, ng/ml 109.79 ± 25.19 233.79 ± 49.43* 206.19 ± 39.02* 154.49 ± 29.08 0.000 0.000
DAO, U/ml 21.10 ± 4.49 38.91 ± 5.65* 34.88 ± 4.35* 23.53 ± 3.88 0.000 0.000
  1. Values are presented as mean ± SD. P < 0.05 indicated significantly different between the trial arms
  2. NC normal control group, PC positive control group, LP low dose intervention group, HP high dose intervention group.
  3. *P < 0.05 versus NC group; P1 value was calculated by a crude general linear model to test the difference in treatment effects between the groups. P2 value was calculated by a full general linear model with adjustments for age, BMI, the liver function, lipid metabolism, and inflammatory factor to test the difference in treatment effects between the groups.