Table 2 Effect of probiotics on liver function and lipid metabolism.

From: Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury

  NC PC LP HP Between-group comparisons
P1 P2
ALT, U/l 20.52 ± 6.45 63.02 ± 11.88* 61.41 ± 13.37* 56.72 ± 13.29* 0.000 0.049
AST, U/l 19.95 ± 4.44 59.78 ± 15.10* 51.57 ± 12.59* 45.68 ± 16.24* 0.000 0.004
GGT, U/l 26.90 ± 9.44 151.85 ± 28.55* 135.07 ± 26.20* 122.98 ± 27.47* 0.000 0.046
TBIL, μmol/l 11.13 ± 1.84 19.63 ± 5.16* 17.82 ± 4.88* 16.08 ± 4.52 0.000 0.021
DBIL, μmol/l 4.25 ± 0.68 6.23 ± 0.90 6.17 ± 1.60 5.55 ± 1.39 0.000 0.328
IBIL, μmol/l 6.88 ± 2.08 13.41 ± 4.78* 11.67 ± 4.90 10.54 ± 3.94 0.000 0.508
TG, mmol/l 1.01 ± 0.33 1.99 ± 0.34* 1.62 ± 0.35* 1.41 ± 0.31 0.000 0.000
TC, mmol/l 4.35 ± 0.65 5.27 ± 0.34* 5.28 ± 0.95* 5.01 ± 0.81* 0.000 0.052
LDLC, mmol/l 2.53 ± 0.47 4.07 ± 0.37* 3.76 ± 0.72 3.10 ± 0.39 0.000 0.000
HDLC, mmol/l 1.52 ± 0.30 1.42 ± 0.53* 1.38 ± 0.23* 1.53 ± 0.35 0.129 0.062
  1. Values are presented as mean ± SD. *P < 0.05 indicated significantly different between the trial arms.
  2. ALT alanine aminotransferase, AST aspartate aminotransferase, GGT gamma-glutamyltransferase, TG triglyceride,TC total cholesterol, HDLC high density lipoprotein cholesterol, LDLC low density lipoprotein cholesterol, TBIL total bilirubin, DBIL direct bilirubin, IBIL indirect bilirubin. NC normal control group, PC positive control group, LP low dose intervention group, HP high dose intervention group. *P < 0.05 versus NC group. P1 value was calculated by a crude general linear model to test the difference in treatment effects between the groups. P2 value was calculated by a full general linear model with adjustments for age, BMI, the liver function, lipid metabolism and inflammatory factor to test the difference in treatment effects between the groups.