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References
Karl Popper. Conjectures and refutations. Growth Sci Knowl 2002;291:136. 374. Routledge Classics, Oxford UK
Guijas C, Montenegro-Burke JR, Warth B, Spilker ME, Siuzdak G. Metabolomics activity screening for identifying metabolites that modulate phenotype. Nat Biotechnol. 2018;36:316–20.
Schüssler Fionza-Rose SM, Contrpois K, Moneghetti KJ, Zhou W, Mishra T, Mataraso S, et al. A longitudinal big data approach for precision health. Nat Med. 2019;792:792–804.
Hou Y-CC, Yu H-C, Martin R, Cirulli ET, Schenker-Ahmed M, Hicks M, et al. Precision medicine integrating whole-genome sequencing, comprehensive metabolomics and advanced imaging. PNAS. 2020;117:3053–62.
Ulaszewska MM, Weinert CN, Trimigno A, Portmann R, Lacueva CA, Badertscher R, et al. Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies. Mol Nutr Food Res. 2019;63:1800384.
Barnes S, Benton HP, Casazza K, Cooper SJ, Cui X, Engler J, et al. Training in metabolomics. I Designment the experiment, collecting and extracting samples, and generating metabolomics data. J Mass Spectrom. 2016;51:461–75.
Jang C, Chen L, Rabinowitz JD. Metabolomics and isotope tracing. Cell. 2018;173:822–37.
Playdon MC, Joshi AD, Tabung FK, Cheng S, Henglin M, Kim A, et al. Metabolomics analytics workflow for epidemiological research: perspectives from the consortium of metabolomics studies (COMETS). Metabolites. 2019;9:145. https://doi.org/10.3390/metabo9070145.
NN. Why the metabolism field risks missing out on AI revolution. Nat Metab. 2019;1:929–30.
Wolfe R, Chinkes DL. Isotope tracers in metabolic research: principles and practice of kinetic analysis. 2nd edition. Hoboken, New Jersey, US: Wiley&Sons; 2004.
Cirulli ET, Guo L, Swisher CL, Shah N, Huang L, Napier LA, et al. Profound perturbation of the metabolome in obesity is associated with health risk. Cell Metab. 2019;29:488–500.
Guasch-Ferre M, Hruby A, Toledo E, Clish CB, Martinez-Gonzales M, Salas-Salvado J, et al. Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis. Diabetes Care. 2016;39:833–46.
Drogan D, Dunn WB, Lin W, Buijsse B, Schulze MB, Langenberg C, et al. Untargeted metabolic profiling identifies altered serum metabolites of type 2 diabetes mellitus in a prospective, nested case control study. Clin Chem. 2015;61:487–97.
Koch M, Freitag-Wolf S, Schlesinger S, Borggrefe J, Hov JR, Jensen MK, et al. Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample. Eur J Clin Nutr. 2017;71:995–1001.
Deelen J, Kettunen J, Fischer K, van der Spek A, Trompet S, Kastenmüller K, et al. A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals. Nat Commun. 2019;10:3346. https://doi.org/10.1038/s41467-019-11311-9.
Guasch-Ferre M, Santos JL, Martinez-Gonzales MA, Clish CB, Razquin C, Wang D, et al. Glycolysis/gluconeogenesis- and tricarboxylic acid cycle-related metabolites, Mediterranean diet, and type 2 diabetes. Am J Clin Nutr. 2020. pii: nqaa016. https://doi.org/10.1093/ajcn/nqaa016.
Cheng S, Larson MG, McCabe EL, Murabito JM, Rhee EP, Ho JE, et al. Distinct metabolomic signatures are associated with longevity in humans. Nat Commun. 2015;6:6791.
Liu X, Sadhukkan S, Sun S, Wagner GR, Hirschey MD, Qi L, et al. High-resolution metabolomics with acyl-CoA profiling reveals wide-spread remodeling in response to diet. Mol Cell Proteom. 2015;14:1489–500.
Green CL, Mitchell SC, Derous D, Wang Y, Chen L, Han J-DJ, et al. the effects of graded levels of calorie restriction: XIV. Global metabolomics screen reveals brown adipose tissue changes in amino acids, catecholamines, and antioxidants after short-term restriction in C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2019;XX:1–12.
Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang S-K, Murphy CJ, et al. High-fructose corn syrup enhances intestinal tumor growth in mice. Science. 2019;363:1343–9.
Zhang K, Han Y, Zhao Q, Zhan T, Li Y, Sun W, et al. Targeted metabolomics analysis reveals that dietary supranutritional selenium regulates sugar and acylcarnitine metabolism homeostasis in pig liver. J Nutr. 2020;150:704–13.
Dhurandhar NV, Schoeller D, Brown AW, Heymsfield SB, Thomas D, Sörensen TIA, et al. Energy balance measurement: when something is not better than nothing. Int J Obes. 2015;39:1109–13.
Satija A, Yu E, Willett WC, Hu FB. Understanding nutritional epidemiology and its role in policy. Adv Nutr. 2015;6:5–18.
Mazzili KM, McClain KM, Lipworth L, Playdon MC, Sampson JN, Clish CB, et al. Identification of 102 correlations between serum metabolites and habitual diet in a metabolomics study of the prostate, lung, colorectal, and ovarian cancer trial. J Nutr. 2020;150:694–703.
Esko T, Hirschhorn JN, Hsu Y-HH, Feldman HA, Ebbeling CB, Ludwig DS, et al. Metabolomic profiles as reliable biomarkers of dietary composition. Am J Clin Nutr. 2017;105:547–54.
Toledo E, Wang DD, Ruiz-Canela M, Clish CB, Razquin C, Zheng Y, et al. Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet. Am J Clin Nutr. 2017;106:973–83.
Gibney M, Allison D, Bier D, Dwyer J Uncertainty in human nutrition research. Nat Food. 2020. https://doi.org/10.1038/s43016-020-0073-2.
Müller MJ, Geisler C, Hübers M, Pourhassan M, Bosy-Westphal A. Body composition-related functions: a problem-oriented approach. Eur J Clin Nutr. 2019;73:166–71.
Müller MJ, Enderle J, Bosy-Westphal A. Changes in energy expenditure with weight gain and weight loss in humans. Curr Obes Rep. 2016;5:413–23.
Frayn K, Evans R. Human metabolism. 4th Ed., Hoboken-NJ, US: Blackwell-Wiley; 2019.
Newsholme EA, Leech AR. Biochemistry for the medical science. 2nd. Ed. Hoboken-New Jersey, US: John Wiley&Sons; 1988.
Seitz HJ, Faupel RP, Kampf SC, Tarnowski W. Influence of different types of narcosis and neck fracture on the concentration of glycolytic intermediates and related compounds in rat liver. Arch Biochem Biophys. 1973;158:12–18.
Faupel RP, Seitz HJ, Tarnowski W, Thiemann V, Weiss CH. The problem of tissue sampling from experimental animals with respect to freezing techniques, anoxia, stress and narcosis. Arch Biochem Piophys. 1972;148:509–22.
Wollenberger A, Ristau O, Schoffa CT. Eine einfache Technik der extrem schnellen Abkühlung größerer Gewebestücke. Pflüger’s Arch Ges Physiol. 1960;270:399–412.
Soares M, Müller MJ. Resting energy expenditure and body composition. Critical aspects for clinical nutrition. Eur J Clin Nutr. 2018;72:1208–14.
Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med. 2013;368:1489–97.
Müller MJ, Braun W, Pourhassan M, Geisler C, Bosy-Westphal A. Application of standards and models in body composition analysis. Proc Nutr Soc. 2016;75:181–7.
Exton JH, Lewis SB, Ho RJ, Robison GA, Park CR. The role of cyclic AMP in the interaction of glucagon and insulin in the control of liver metabolism. Ann NY Acad Sci. 1971;185:85–100.
Gumaa GA, McLean P, Greenbaum AL. Compartmentation in relation to metabolic control in liver. Essays Biochem. 1971;7:39–86.
Seitz HJ, Müller MJ, Krone W, Tarnowski W. Coordinate control of intermediary metabolism in rat liver by the insulin/glucagon ratio during starvation and after glucose refeeding. Regulatory significance of long-chain acyl-CoA and cyclic AMP. Arch Biochem Biophys. 1977;183:647–63.
Seitz HJ, Kaiser M, Krone W, Tarnowski W. Physiologic significance of glucocorticoids and insulin in the regulation of hepatic gluconeogenesis during starvation in rats. Metabolism. 1976;25:1545–155.
Wahren J, Ekberg K. Splanchnic regulation of glucose production. Ann Rev Nutr. 2007;27:329–45.
Coppack SW, Fisher RM, Humphreys SM, Clark ML, Pointon JJ, Frayn K. Carbohydrate metabolism in insulin resistance: glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal. Clin Sci. 1996;90:409–15.
Müller MJ. Hepatic energy and substrate metabolism: a possible metabolic basis for early nutritional support in cirrhotic patients. Nutrition. 1998;14:30–8.
Selberg O, Burchert W, vd Hoff J, Meyer GJ, Hundeshagen H, Radoch E, et al. Insulin resistance in liver cirrhosis. Positron-emission tomography scan analysis of skeletal muscle glucose metabolism. J Clin Invest. 1993;91:1897–902.
Johannsen DL, Marlatt KR, Conley KE, Smith SR, Ravussin E. Metabolic adaptation is not observed after 8 weeks of overfeeding but energy expenditure variability is associated with weight recovery. Am J Clin Nutr. 2019;110:805–13.
Umplepy AM. Tracing lipid metabolism. The value of stable isotopes. J Endocrinol. 2015;216:G1–10.
Davis PSW. Stable isotopes: their use and safety in human nutrition studies. Eur J Clin Nutr. 2020;74:362–5.
Charidemou E, Ashmore T, Griffin JL. The use of stable isotopes in the study of human pathophysiology. Int J Biochem Cell Biol. 2017;93:102–9.
Ulijaszek S. Productive simplification in the use of anthropometric nutritional status. Eur J Clin Nutr. 2020;74:359–61.
Müller MJ, Braun W, Enderle J, Bosy-Westphal A. Beyond BMI: conceptual issues related to overweight and obese patients. Obes facts. 2016;9:193–205.
Müller MJ, Geissler C, Blundell J, Dulloo A, Schutz Y, Krawczak M, et al. The case of GWAS of obesity: does body weight control play by the rules? Int J Obes. 2018;42:1395–405.
Hannah Arendt. The human condition. 1st Ed. Chicago, IL, US: University Press; 1958.
Acknowledgements
We wish to thank Prof. Hans-Joachim Seitz, University Hospital Hamburg Eppendorf, Hamburg, Germany, for referring to his previous and fundamental work on the effects of anoxia, narcotics, euthanization, tissue sampling, and its preparation on the tissue concentrations of intermediates. Many thanks to Prof. John Blundell, Institute of Psychological Sciences, University of Leeds, Leeds, UK, for in depth discussions, ongoing motivation and his critical views on the benefits of the big data research. In addition, thanks to Prof. Mario Soares, School of Public Health, Faculty of Health Sciences, Curtin University, Perth, WA, Australia, for his valuable discussion and proof reading of the ms.
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Müller, M.J., Bosy-Westphal, A. From a “Metabolomics fashion” to a sound application of metabolomics in research on human nutrition. Eur J Clin Nutr 74, 1619–1629 (2020). https://doi.org/10.1038/s41430-020-00781-6
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DOI: https://doi.org/10.1038/s41430-020-00781-6
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