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Response to editor “A systematic review and meta-analysis of the response of serum 25-hydroxyvitamin D concentration to vitamin D supplementation from RCTs from around the globe”

European Journal of Clinical Nutrition volume 74, pages 1615–1617 (2020)Cite this article

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The authors thank the readers for their letter and comments regarding “A systematic review and meta-analysis of the response of serum 25-hydroxyvitamin D concentration to vitamin D supplementation from RCTs from around the globe.” Those comments are valuable, and we try our best to figure out probable issues. We have answered carefully the letter, based on the comments from readers.

In the selection of studies for children, authors have omitted six studies, two from Middle East and North Africa region [1, 2], one from Finland [3], one from Australia [4], and two from the United States [5, 6], with over 800 participants, which examined the safety and efficacy of various doses of VitD supplementation for improving the serum 25(OH)D. The exclusion criteria did not justify excluding these studies. The exclusion of four large studies may skew the estimates and make them unreliable.

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References

  1. El-Hajj Fuleihan G, Nabulsi M, Tamim H, Maalouf J, Salamoun M, Khalife H, et al. Effect of vitamin D replacement on musculoskeletal parameters in school children: a randomized controlled trial. J Clin Endocrinol Metab. 2006;91:405–12.

    Article  PubMed  Google Scholar 

  2. Maalouf J, Nabulsi M, Vieth R, Kimball S, El-Rassi R, Mahfoud Z, et al. Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children. J Clin Endocrinol Metab. 2008;93:2693–701.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Viljakainen HT, Natri AM, Karkkainen M, Huttunen MM, Palssa A, Jakobsen J, et al. A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention. J Bone Miner Res. 2006;21:836–44.

    Article  CAS  PubMed  Google Scholar 

  4. Wu FT, Xiao C, Aitken D, Jones G, Winzenberg T. The optimal dosage regimen of vitamin D supplementation for correcting deficiency in adolescents: a pilot randomized controlled trial. Eur J Clin Nutr. 2018;72:534–40.

    Article  CAS  PubMed  Google Scholar 

  5. Lewis RD, Laing EM, Gallant KMH, Hall DB, McCabe GP, Hausman DB, et al. A randomized trial of vitamin D-3 supplementation in children: dose-response effects on vitamin D metabolites and calcium absorption. J Clin Endocrinol Metab. 2013;98:4816–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Dong Y, Stallmann-Jorgensen IS, Pollock NK, Harris RA, Keeton D, Huang Y, et al. A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness. J Clin Endocrinol Metab. 2010;95:4584–91.

    Article  CAS  PubMed  Google Scholar 

  7. Saad K, Abdel-Rahman AA, Elserogy YM, Al-Atram AA, El-Houfey AA, Othman HAK, et al. Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder. J Child Psychol Psychiatry. 2018;59:20–9.

    Article  PubMed  Google Scholar 

  8. Alzghoul L. Role of vitamin D in autism spectrum disorder. Curr Pharm Des. 2019;25:4357–67.

    Article  CAS  PubMed  Google Scholar 

  9. Saad K, Abdel-Rahman A, Elserogy Y, Al-Atram A, El-Houfey A, Othman H. et al. Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder (Retraction of Vol 59, Pg 20, 2017). J Child Psychol Psychiatry. 2019;60:711.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Public Health, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

    Minjia Mo & Yunxian Yu

  2. Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, Hangzhou, China

    Minjia Mo & Yunxian Yu

  3. Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

    Minjia Mo & Yunxian Yu

  4. Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou, China

    Minjia Mo & Yunxian Yu

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  1. Minjia Mo
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Correspondence to Yunxian Yu.

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Mo, M., Yu, Y. Response to editor “A systematic review and meta-analysis of the response of serum 25-hydroxyvitamin D concentration to vitamin D supplementation from RCTs from around the globe”. Eur J Clin Nutr 74, 1615–1617 (2020). https://doi.org/10.1038/s41430-020-00769-2

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  • DOI: https://doi.org/10.1038/s41430-020-00769-2

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