Body composition, energy expenditure and physical activity

The association between low lean mass and osteoporosis increases the risk of weakness, poor physical performance and frailty in Brazilian older adults: data from SARCOS study

Abstract

Purpose

To characterize the phenotypes of older adults with low lean mass and osteoporosis, concomitantly or isolated, in regards to poor physical performance and frailty status.

Design

Cross-sectional analysis of the SARCopenia and OSteoporosis in Older Adults with Cardiovascular Diseases Study (SARCOS).

Setting

Outpatient geriatric cardiology clinic.

Participants and method

385 older adults underwent DXA analysis. Low lean mass was diagnosed according to FNIH and low BMD by a T-score ≤ −2.5 SD. Subjects were grouped into: I—Low lean mass and Osteoporosis (LLMO); II—Low lean mass (LLM); III—Osteoporosis (OP), and IV—Controls. Poor physical performance was diagnosed by weakness or slow walking speed or impaired mobility. Frailty was diagnosed by CHS criteria.

Results

The mean age was 78.22 ± 7.16 years. The prevalence of LLMO, LLM, and OP were 14.8%, 39.5%, and 19.2%, respectively. LLMO subjects were older, predominantly women, with a high percentage of body fat (HTBF). LLM was represented by obese men, while individuals with OP were preferably women, older and leaner. In a regression analyses, LLMO presented an OR: 6.42 (2.63‒15.65; p < 0.001) for weakness, OR: 2.55 (1.09‒5.95; p = 0.030) for impaired mobility, and OR: 14.75 (2.72‒79.94; p = 0.002) for frailty. After adjusting for HTBF, the OR for frailty, decreased to 7.25 (1.11–47.21; p = 0.038). LLM and OP were associated only with weakness with an OR: 3.06 (1.36–6.84; p = 0.006) and OR: 3.14 (1.29–7.62; p = 0.011), respectively.

Conclusion

In Brazilian older community-dwelling outpatient adults, the phenotype characterized by low lean mass and osteoporosis presents a higher association with impaired mobility, weakness and frailty status compared to the others phenotyeps and controls. A high percentage of body fat presents a synergistic effect with low lean mass and osteoporosis phenotype in regards to frailty.

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Fig. 1: The flowchart of selection of musculoskeletal phenotypes.

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Acknowledgements

The authors would like to thank Tania Brunini Berna and Neusa Maria for help with the administrative aspects and organization of our study.

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Correspondence to Alberto Frisoli Jr.

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Frisoli Jr, A., Paes, A.T., Borges, J. et al. The association between low lean mass and osteoporosis increases the risk of weakness, poor physical performance and frailty in Brazilian older adults: data from SARCOS study. Eur J Clin Nutr (2020). https://doi.org/10.1038/s41430-020-00753-w

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