Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Determination of aluminum concentrations of parenteral nutrition solutions by HPLC

European Journal of Clinical Nutrition volume 75, pages 567–569 (2021)Cite this article

Subjects

Abstract

Aluminum (Al) contamination of parenteral nutrition (PN) solutions has been known for over 30 years. In particular, vascular intake of Al leads to its accumulation in tissues. In this study, 8 all-in-one PN solutions the aluminum concentration was analyzed by high-performance liquid chromatography. The mean Al concentration of the glucose solutions of the PN solutions combinations was 16.36 ± 8.31 µg/L, the mean Al concentration of the amino acid solutions was 4.96 ± 3.73 µg/L, and the mean Al concentration of the lipid solutions was 9.09 ± 11.23 µg/L. The Al concentration of the PN5 glucose and PN2 lipid solutions were above 25 µg/L, which is the limit set by the Food and Drug Administration (FDA). No studies in the literature have examined the Al concentrations of all-in-one PN solutions via HPLC. In two of the analyzed solutions, the Al concentration was found to be higher than the limit set by the FDA.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Aluminum concentrations of 8 different all-in-one PN solutions (PN1-8).

Similar content being viewed by others

References

  1. Klein GL. Aluminum in parenteral solutions revisited-again. Am J Clin Nutr. 1995;61:449–56.

    Article  CAS  Google Scholar 

  2. Klein GL, Alfrey AC, Miller NL, Sherrard DJ, Hazlet TK, Ament ME, et al. Aluminum loading during total parenteral-nutrition. Am J Clin Nutr. 1982;35:1425–9.

    Article  CAS  Google Scholar 

  3. Working Group on Standards for Aluminum Content of Parenteral Nutrition Solutions. Parenteral drug products containing aluminum as an ingredient or a contaminant: response to Food and Drug Administration notice of intent and request for information. ASCN/A.S.P.E.N. JPEN J Parenter Enter Nutr. 1991;15:194–8.

    Article  Google Scholar 

  4. Charney PJ, American Society for P, Enteral Nutrition Aluminum Task F. A.s.p.e.N. Statement on aluminum in parenteral nutrition solutions. Nutr Clin Pract. 2004;19:416–7.

    Article  Google Scholar 

  5. Hernandez-Sanchez A, Tejada-Gonzalez P, Arteta-Jimenez M. Aluminium in parenteral nutrition: a systematic review. Eur J Clin Nutr. 2013;67:230–8.

    Article  CAS  Google Scholar 

  6. Food and Drug Administration, HHS. Aluminum in large and small volume parenterals used in total parenteral nutrition. Food and Drug Administration Fed Regist. 2000;65:4103–11.

  7. Bohrer D, do Nascimento PC, Binotto R, Becker E. Influence of the glass packing on the contamination of pharmaceutical products by aluminium. Part III: interaction container-chemicals during the heating for sterilisation. J Trace Elem Med Biol. 2003;17:107–15.

    Article  CAS  Google Scholar 

  8. de Oliveira SR, Bohrer D, Garcia SC, do Nascimento PC, Noremberg S. Aluminum content in intravenous solutions for administration to neonates: role of product preparation and administration methods. JPEN J Parenter Enter Nutr. 2010;34:322–8.

    Article  Google Scholar 

  9. Poole RL, Schiff L, Hintz SR, Wong A, Mackenzie N, Kerner JA Jr. Aluminum content of parenteral nutrition in neonates: measured versus calculated levels. J Pediatr Gastroenterol Nutr. 2010;50:208–11.

    Article  CAS  Google Scholar 

  10. Shibukawa M, Koyahara K, Mishina A, Saitoh K, Nishigaki A. Determination of trace amounts of aluminum in environmental and biological fluids by reversed-phase ion-pair liquid chromatography with fluorometric detection using 5-sulfoquinoline-8-ol. Curr Chromatogr. 2016;03:123.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nutrition and Dietetics, Karadeniz Technical University, Faculty of Health Sciences, Trabzon, Turkey

    Elif Öztürk

  2. Department of Analytical Chemistry, Karadeniz Technical University, Faculty of Pharmacy, Trabzon, Turkey

    Sercan Yıldırım

  3. Department of Nutrition and Dietetics, Hacettepe University, Faculty of Health Sciences, Ankara, Turkey

    Aslı Akyol

Authors
  1. Elif Öztürk
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sercan Yıldırım
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aslı Akyol
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elif Öztürk.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Öztürk, E., Yıldırım, S. & Akyol, A. Determination of aluminum concentrations of parenteral nutrition solutions by HPLC. Eur J Clin Nutr 75, 567–569 (2021). https://doi.org/10.1038/s41430-020-00741-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41430-020-00741-0

This article is cited by

Search

Advanced search

Quick links