Ulcerative colitis (UC) is an immune-mediated disease that causes inflammation in the gastrointestinal tract. Diet has an important role in the treatment of UC. This study aimed to compare the effects of extra virgin olive oil (EVOO), as a functional food, with canola oil in the treatment of UC.
Forty patients were participating in this crossover clinical trial. Thirty two patients completed two intervention rounds. Blood samples were taken before and after 20 days intervention. Disease activity score and gastrointestinal symptoms were evaluated using the Mayo score and gastrointestinal symptom rating scale (GSRS) respectively.
Erythrocyte sedimentation rate (p = 0.03) and high-sensitivity C-reactive protein (p < 0.001) were decreased significantly after EVOO consumption. Bloating, constipation, fecal urgency, incomplete defecation, and final GSRS were reduced significantly after EVOO consumption (p < 0.05).
Intake of EVOO decreased the inflammatory markers and improved gastrointestinal symptoms in UC patients. It seems this functional food can be beneficial in the treatment of UC as a complementary medicine.
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This paper is a part of the master thesis of Mehrnaz Morvaridi. Authors special thanks go to all patients participated in this study.
Ahvaz Jundishapur University of Medical Sciences was financially supported this clinical trial and was registered in Nutrition and Metabolic Diseases Research Center of this university (ID: NRC-9619).
Conflict of interest
The authors declare that they have no conflict of interest.
This clinical trial was approved by the Ethics Committee of Ahvaz Jundishapur University of Medical Sciences (IR.AJUMS.REC.1396.624) according to the Declaration of Helsinki, and confirmed in the Iranian Registry of Clinical Trials (IRCT20170730035381N1). All patients filled and signed a formal consent form and their information were kept secret in all stages of the study.
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Morvaridi, M., Jafarirad, S., Seyedian, S.S. et al. The effects of extra virgin olive oil and canola oil on inflammatory markers and gastrointestinal symptoms in patients with ulcerative colitis. Eur J Clin Nutr 74, 891–899 (2020). https://doi.org/10.1038/s41430-019-0549-z