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Association between intraoperative magnesium sulfate infusion and mortality after non-cardiac surgery: a retrospective propensity score matched analysis


The short-term effects of magnesium sulfate infusion during surgery are well known. However, the long-term outcomes of intraoperative magnesium sulfate infusion remain unknown. Medical records of patients aged ≥20 years who underwent non-cardiac surgical procedures at Seoul National University Bundang Hospital between January, 2010 and October, 2016 were analyzed. After propensity score matching, 12,652 patients were included in the final analysis, 6326 each in the magnesium and non-magnesium groups. There were no significant differences in 30-day or 1-year mortality between subjects [30-day mortality, hazard ratio (HR): 1.31, 95% CI: 0.64–2.69, P = 0.465; 1-year mortality, HR: 1.20, 95%CI: 0.94–1.53, P = 0.136]. Intraoperative magnesium sulfate infusion was not significantly associated with postoperative 30-day or 1-year mortality.

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  1. Guasch-Ferre M, Bullo M, Estruch R, Corella D, Martinez-Gonzalez MA, Ros E, et al. Dietary magnesium intake is inversely associated with mortality in adults at high cardiovascular disease risk. J Nutr. 2014;144:55–60.

    Article  CAS  PubMed  Google Scholar 

  2. You S, Zhong C, Du H, Zhang Y, Zheng D, Wang X, et al. Admission low magnesium level is associated with in-hospital mortality in acute ischemic stroke patients. Cerebrovasc Dis. 2017;44:35–42.

    Article  CAS  PubMed  Google Scholar 

  3. Schmaderer C, Braunisch MC, Suttmann Y, Lorenz G, Pham D, Haller B, et al. Reduced mortality in maintenance haemodialysis patients on high versus low dialysate magnesium: a pilot study. Nutrients. 2017;9:E926.

  4. Yu L, Li H, Wang SX. Serum magnesium and mortality in maintenance hemodialysis patients. Blood Purif. 2017;43:31–6.

    Article  CAS  PubMed  Google Scholar 

  5. Rubenowitz E, Molin I, Axelsson G, Rylander R. Magnesium in drinking water in relation to morbidity and mortality from acute myocardial infarction. Epidemiology. 2000;11:416–21.

    Article  CAS  Google Scholar 

  6. Kaluza J, Orsini N, Levitan EB, Brzozowska A, Roszkowski W, Wolk A. Dietary calcium and magnesium intake and mortality: a prospective study of men. Am J Epidemiol. 2010;171:801–7.

    Article  PubMed  Google Scholar 

  7. Hirashima J, Yamana H, Matsui H, Fushimi K, Yasunaga H. Effect of intravenous magnesium sulfate on mortality in patients with severe acute asthma. Respirology. 2016;21:668–73.

    Article  PubMed  Google Scholar 

  8. Naksuk N, Hu T, Krittanawong C, Thongprayoon C, Sharma S, Park JY, et al. Association of serum magnesium on mortality in patients admitted to the intensive cardiac care unit. Am J Med. 2017;130:229.e5–13.

    Article  CAS  Google Scholar 

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T.K.O. designed the study and drafted the manuscript; E.J. contributed to the acquisition of data and analyzed the data; S.-H.D. contributed to the interpretation of data and provided critical revisions of the manuscript. All authors have given final approval for the final version of the manuscript.

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Correspondence to Sang-Hwan Do.

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The authors declare that they have no conflict of interest.

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Oh, T.K., Ji, E. & Do, SH. Association between intraoperative magnesium sulfate infusion and mortality after non-cardiac surgery: a retrospective propensity score matched analysis. Eur J Clin Nutr 73, 483–486 (2019).

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