Diagnosis of histamine intolerance (HIT) has been based on low serum diamine oxidase (DAO) values, functional gastrointestinal disorders and improvement of symptoms with a histamine-reduced diet (HRD). In a retrospective analysis of outpatients’ charts we identified 101 patients with HIT. After a median of 13 months, a questionnaire was distributed to the patients so that they could be classified into four diet-compliance groups. Calculated with all 101 patients we found an increase of serum DAO values due to a HRD. In the 63 patients that completed the questionnaire, we found that 50 patients had improvement of symptoms or no continuing symptoms. A significant increase of serum DAO levels was found in the patients with strict and occasional diet compliance. Therefore, we demonstrate that a HRD is not only improving symptoms in HIT, but is causing an increase in serum DAO values that correlates with the degree of diet compliance.
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Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007;85:1185–96.
Reese I, Ballmer-Weber B, Beyer K, Fuchs T, Kleine-Tebbe J, Klimek L, et al. German guideline for the management of adverse reactions to ingested histamine. Allergo J Int. 2017;26:72–79.
San Mauro Martin I, Brachero S, Garicano Vilar E. Histamine intolerance and dietary management: a complete review. Allergol Immunopathol (Madr). 2016;44:475–83.
Kohn JB. Is there a diet for histamine intolerance? J Acad Nutr Diet. 2014;114:1860.
Kovacova-Hanuskova E, Buday T, Gavliakova S, Plevkova J. Histamine, histamine intoxication and intolerance. Allergol Immunopathol (Madr). 2015;43:498–506.
Enko D, Meinitzer A, Mangge H, Kriegshäuser G, Halwachs-Baumann G, Reininghaus EZ, et al. Concomitant prevalence of low serum diamine oxidase activity and carbohydrate malabsorption. Can J Gastroenterol Hepatol. 2016;2016:4893501.
Schnedl WJ, Lackner S, Enko D, Schenk M, Mangge H, Holasek SJ. Non-celiac gluten sensitivity. People without celiac disease avoiding gluten—is it due to histamine intolerance? Inflamm Res. 2018;67:279–84.
Wollin A, Wang X, Tso P. Nutrients regulate diamine oxidase release from intestinal mucosa. Am J Physiol. 1988;275:R969–R975.
Wagner N, Dirk D, Peveling-Oberhag A, Reese I, Rady-Pizarro U, Mitzel H, et al. A Popular myth—low-histamine diet improves chronic spontaneous urticaria—fact or fiction? J Eur Acad Dermatol Venereol. 2016;31:650–5.
Shelef O, Weisberg PJ, Frederick D, Provenza FD. The value of native plants and local production in an era of global agriculture. Front Plant Sci. 2017;8:2069.
Conflict of interest
Wolfgang J. Schnedl received speaking honoraria from Sciotec. Remaining authors declare no conflict of interest.
Parts of this study were used by Dr. Verena Malcher to fulfill the requirements for obtaining the degree “Dr. med.” at Medical University in Graz, Austria
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Lackner, S., Malcher, V., Enko, D. et al. Histamine-reduced diet and increase of serum diamine oxidase correlating to diet compliance in histamine intolerance. Eur J Clin Nutr 73, 102–104 (2019). https://doi.org/10.1038/s41430-018-0260-5