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Food and Agriculture Organization Committee on Calorie Requirements. Calorie Requirements: Report of the Second Committee on Calorie Requirements. Rome: Food and Agriculture Organization of the United Nations; 1957.
Harris JA, Benedict FG. A biometric study of human basal metabolism. Proc Natl Acad Sci USA. 1918;4:370–3.
Nielsen S, Hensrud DD, Romanski S, Levine JA, Burguera B, Jensen MD. Body composition and resting energy expenditure in humans: role of fat, fat-free mass and extracellular fluid. Int J Obes Relat Metab Disord. 2000;24:1153–7.
Kleiber M. Body size and metabolism. Hilgardia. 1932;6:315–53.
Calder WA. Size, function, and life history. Cambridge, MA: Harvard University Press; 1984.
Glazier DS. Beyond the ‘3/4-power law’: variation in the intra- and interspecific scaling of metabolic rate in animals. Biol Rev Camb Philos Soc. 2005;80:611–62.
Heymsfield SB, Gallagher D, Mayer L, Beetsch J, Pietrobelli A. Scaling of human body composition to stature: new insights into body mass index. Am J Clin Nutr. 2007;86:82–91.
Heymsfield SB, Peterson CM, Thomas DM, Heo M, Schuna JM Jr., Hong S, et al. Scaling of adult body weight to height across sex and race/ethnic groups: relevance to BMI. Am J Clin Nutr. 2014;100:1455–61.
Heymsfield SB, Childers D, Beetsch J, Allison DB, Pietrobelli A. Body size and human energy requirements: reduced mass-specific resting energy expenditure in tall adults. J Appl Physiol. 1985;2007:1543–50.
International Commission on Radiological Protection. Report of the Task Group on Reference Man: A Report. New York: Pergamon Press; 1975.
Elia M. Organ and tissue contribution to metabolic rate. In: Kinney JM, Tucker HN, (eds). Energy metabolism: tissue determinants and cellular corollaries.. New York: Raven Press; 1992. p. 61–79.
Heymsfield SB, Bourgeois B, Peterson CM. Body composition-energy expenditure organ system model: initial evaluation of predictions. Obes Rev. in press.
Muller MJ, Bosy-Westphal A, Kutzner D, Heller M. Metabolically active components of fat-free mass and resting energy expenditure in humans: recent lessons from imaging technologies. Obes Rev. 2002;3:113–22.
Kennedy D, Norman C. What don’t we know? Science. 2005;309:75.
Heymsfield SB, Chirachariyavej T, Rhyu IJ, Roongpisuthipong C, Heo M, Pietrobelli A. Differences between brain mass and body weight scaling to height: potential mechanism of reduced mass-specific resting energy expenditure of taller adults. J Appl Physiol. 1985;2009:40–48.
Heymsfield SB, Muller MJ, Bosy-Westphal A, Thomas D, Shen W. Human brain mass: similar body composition associations as observed across mammals. Am J Hum Biol. 2012;24:479–85.
Bosy-Westphal A, Reinecke U, Schlorke T, Illner K, Kutzner D, Heller M, et al. Effect of organ and tissue masses on resting energy expenditure in underweight, normal weight and obese adults. Int J Obes Relat Metab Disord. 2004;28:72–79.
Webb JG, Kiess MC, Chan-Yan CC. Malnutrition and the heart. CMAJ. 1986;135:753–8.
Keys AB, Brožek J, Henschel A, Mickelsen O, Taylor HL. The biology of human starvation. Minneapolis, MN: University of Minnesota Press; 1950.
Fohlin L, Freyschuss U, Bjarke B, Davies CT, Thoren C. Function and dimensions of the circulatory system in anorexia nervosa. Acta Paediatr Scand. 1978;67:11–16.
Lui JC, Baron J. Mechanisms limiting body growth in mammals. Endocr Rev. 2011;32:422–40.
Hafen E, Stocker H. How are the sizes of cells, organs, and bodies controlled? PLoS Biol. 2003;1:E86.
Penzo-Mendez AI, Stanger BZ. Organ-size regulation in mammals. Cold Spring Harb Perspect Biol. 2015;7:a019240.
Dekaban AS. Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Ann Neurol. 1978;4:345–56.
Lui JC, Garrison P, Baron J. Regulation of body growth. Curr Opin Pediatr. 2015;27:502–10.
Watt KI, Harvey KF, Gregorevic P. Regulation of tissue growth by the mammalian hippo signaling pathway. Front Physiol. 2017;8:942.
Carnac G, Ricaud S, Vernus B, Bonnieu A. Myostatin: biology and clinical relevance. Mini Rev Med Chem. 2006;6:765–70.
Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology. 2006;43:S45–53.
Fausto N, Campbell JS, Riehle KJ. Liver regeneration. J Hepatol. 2012;57:692–4.
Alpert MA, Omran J, Bostick BP. Effects of obesity on cardiovascular hemodynamics, cardiac morphology, and ventricular function. Curr Obes Rep. 2016;5:424–34.
Ford LE. Heart size. Circ Res. 1976;39:297–303.
Manetti P, Toncelli L, Vono MC, Capalbo A, Boddi V, Rostagno C, et al. [The effects of training on skeletal and cardiac muscle mass in professional soccer players]. Ann Ital Med Int. 1999;14:166–71.
Frost HM. From Wolff’s law to the Utah paradigm: insights about bone physiology and its clinical applications. Anat Rec. 2001;262:398–419.
Weibel ER. Symmorphosis: on form and function in shaping life. Cambridge, MA: Harvard University Press; 2000.
West GB, Brown JH, Enquist BJ. A general model for the origin of allometric scaling laws in biology. Science. 1997;276:122–6.
Gallagher D, Albu J, He Q, Heshka S, Boxt L, Krasnow N, et al. Small organs with a high metabolic rate explain lower resting energy expenditure in African American than in white adults. Am J Clin Nutr. 2006;83:1062–7.
Heymsfield SB, Peterson CM, Thomas DM, Heo M, Schuna JM Jr.. Why are there race/ethnic differences in adult body mass index-adiposity relationships? A quantitative critical review. Obes Rev. 2016;17:262–75.
Ilardo MA, Moltke I, Korneliussen TS, Cheng J, Stern AJ, Racimo F, et al. Physiological and genetic adaptations to diving in sea nomads. Cell. 2018;173:569–80.e515.
Muller MJ, Bosy-Westphal A, Later W, Haas V, Heller M. Functional body composition: insights into the regulation of energy metabolism and some clinical applications. Eur J Clin Nutr. 2009;63:1045–56.
SBH acknowledges Melanie Peterson for her support in preparing this manuscript and Drs. Anja Bosy-Westphal and Manfred J. Muller for their generous data support used in this review.
This work was partially supported by two National Institutes of Health NORC Center Grants P30DK072476, Pennington/Louisiana; and P30DK040561, Harvard; and R01DK109008, Shape UP! Adults.
SBH drafted the manuscript and edited the manuscript for intellectual content.
Conflict of interest
The author is on the Medical Advisory Boards of Tanita and Medifast Corporations.
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Heymsfield, S.B. Energy expenditure—body size associations: molecular coordination. Eur J Clin Nutr 72, 1314–1319 (2018). https://doi.org/10.1038/s41430-018-0214-y
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