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Protein, malnutrition and wasting disorders

Prognostic impact of early nutritional support in patients affected by locally advanced and metastatic pancreatic ductal adenocarcinoma undergoing chemotherapy

European Journal of Clinical Nutrition volume 72, pages 772–779 (2018)Cite this article

Subjects

Abstract

Background/objectives

The aim of this analysis was to determine the risk of malnutrition and the prognostic value of nutritional intervention in patients affected by pancreatic ductal adenocarcinoma (PDAC) undergoing chemotherapy.

Subjects/methods

Clinical–pathological and nutritional data were correlated with overall survival (OS) using a Cox model. Nutritional status was determined by Malnutrition Universal Screening Tool (MUST), body mass index, weight loss in the past 6 months, presence of nutrition-related symptoms, and current energy intake. Nutritional intervention included appropriate individual dietary counseling.

Results

Data from 109 patients were gathered (median age 63 years). The majority of patients (64.2%) presented a MUST value of ≥ 2, corresponding to a high risk of malnutrition. At multivariate analysis for OS in locally advanced and metastatic PDAC patients, the time between the diagnosis and the nutritional intervention (HR 2.22, p = 0.017), the performance status (HR 1.38, p = 0.075), the surgery of the primary (HR 5.89, p = 0.005), and the response to the first line (HR 5.9, p = 0.03) were independent significant predictors of outcome. Furthermore, a weight gain > 2% from the baseline weight was correlated with the time between the diagnosis and the nutritional intervention (p = 0.021): in patients receiving a nutritional support within 3 months from diagnosis, a 2% weight gain was associated with a 2-year OS benefit (50.3% vs. 33.0%, p = 0.04).

Conclusions

This analysis suggests that the early nutritional support may contribute to influence the prognosis of patients affected by advanced PDAC undergoing chemotherapy.

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Author notes

    Authors and Affiliations

    1. U.O.C. Oncology, University of Verona Azienda Ospedaliera Universitaria Integrata, Verona, Italy

      Ilaria Trestini, Luisa Carbognin, Clelia Bonaiuto, Alessandra Auriemma, Davide Melisi, Lisa Salvatore, Emilio Bria & Giampaolo Tortora

    2. Department of Biostatistics, Regina Elena National Cancer Institute, Roma, Italy

      Isabella Sperduti

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    1. Ilaria Trestini
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    Correspondence to Emilio Bria.

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    The study was approved by the local Ethics Committee (Prot. 1341 CESC).

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    The authors declare that they have no conflict of interest.

    Additional information

    These authors contributed equally: Ilaria Trestini, Luisa Carbognin.

    These authors contributed equally: Emilio Bria, Giampaolo Tortora.

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    Trestini, I., Carbognin, L., Sperduti, I. et al. Prognostic impact of early nutritional support in patients affected by locally advanced and metastatic pancreatic ductal adenocarcinoma undergoing chemotherapy. Eur J Clin Nutr 72, 772–779 (2018). https://doi.org/10.1038/s41430-018-0155-5

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