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Carbohydrates, glycemic index and diabetes mellitus

Glycaemic, uricaemic and blood pressure response to beverages with partial fructose replacement of sucrose



The European Food Safety Authority approved a health claim (ID558) relating to lowered postprandial glycaemia when fructose replaces 30% of sucrose in foods and beverages. We assessed the effects of partial replacement of sucrose with fructose on serum glucose, uric acid and blood pressure.


A randomised, crossover, double blind trial of 12 normoglycaemic participants consuming beverages containing 50 g blends of fructose and sucrose in proportions; 67% sucrose/33% fructose (67%S:33%F); 50% each (50%S:50%F) and 33%S:67%F; a 100% sucrose reference beverage was tested twice. Serum glucose and uric acid concentrations were measured at 0, 15, 30, 45, 60, 90 and 120 min and incremental area-under-the-curve (iAUC) calculated.


The geometric mean (95% CI) glycaemic iAUC following the 100% sucrose, 67%S:33%F, 50%S:50%F and 33%S:67%F blended beverages were 96 (63,145), 71 (46,109), 60 (39, 93) and 39 (12, 86) mmol/L min, respectively. At 33% fructose replacement, the proportionally lower iAUC of −28.5% (95% CI: −62.1, 5.2) mmol/L min was not different to sucrose alone. The response was lowered by fructose replacement of 50 and 67% and overall there was an inverse association (p < 0.001). The mean uricaemic iAUC to the respective beverages were 1320 (393, 2248), 3062 (1553, 4570), 3646 (2446, 4847), 3623 (2020, 5226) µmol/L min. Uric acid concentration was raised by all fructose-containing beverages with 33% fructose replacement causing an increase of 1741 (95% CI: 655, 2829) µmol/L min compared with sucrose alone. Blood pressure was not different among beverages.


Reduced postprandial glycaemia was achieved by the substitution of sucrose with fructose although elevated uricaemic responses should be cautioned.

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This study was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR) reference ACTRN12616001502426.


The study was funded by the University of Otago.

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Correspondence to Bernard Joseph Venn.

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The authors declare that they have no conflict of interest.

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Rodrigues, N., Peng, M., Oey, I. et al. Glycaemic, uricaemic and blood pressure response to beverages with partial fructose replacement of sucrose. Eur J Clin Nutr 72, 1717–1723 (2018).

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