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Fish consumption and depression in Korean adults: the Korea National Health and Nutrition Examination Survey, 2013–2015

European Journal of Clinical Nutrition volume 72, pages 1142–1149 (2018)Cite this article

Subjects

Abstract

Background/objectives

There is a growing body of evidence that supports the potential role of fish consumption in relation to depression, but the data in Korean population is scarce. Thus, we examined the association between fish consumption and depression in Korean adults.

Subjects/methods

We conducted a cross-sectional study in 9183 Korean adults aged 19–64 years who participated in the 6TH Korea National Health and Nutrition Examination Survey (2013–2015), which is a large nationally representative study of Korean population. Fish consumption and depression status were assessed using questionnaires. Multivariable logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CIs) for physician-diagnosed clinical depression.

Results

Out of the 9183 subjects, 389 (4.2%) were diagnosed with depression. After adjusting for potential confounders, the multivariable-adjusted ORs for clinical depression across fish consumption were 1.00 (reference) for <1 time/week, 0.76 (95% CI: 0.56–1.04) for 1–3 times/week and 0.52 (95% CI: 0.37–0.74) for ≥4 times/week (P for trend = 0.0005). The inverse association for ≥4 times/week of fish consumption was stronger in women (OR = 0.44, 95% CI: 0.29–0.67, P for trend < .0001), but there was no significant association in men.

Conclusions

Our findings suggest that high consumption of fish is associated with lower odds of depression in Korean adults, particularly in women. These results warrant further prospective studies to verify the association between fish consumption and risk of depression in Korean adults.

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References

  1. World Health Organization. Depression and other common mental disorders—global health estimates. http://apps.who.int/iris/bitstream/10665/254610/1/WHO-MSD-MER-2017.2-eng.pdf?ua=1. Accessed 10 March 2017.

  2. Global Burden of Disease (GBD) Results Tool 2015. http://ghdx.healthdata.org/gbd-results-tool. Accessed 20 March 2017.

  3. Jeon HJ, Lee JY, Lee YM, Hong JP, Won SH, Cho SJ, et al. Lifetime prevalence and correlates of suicidal ideation, plan, and single and multiple attempts in a Korean nationwide study. J Nerv Ment Dis. 2010;198:643–46.

    Article  Google Scholar 

  4. Krogh J, Nordentoft M, Sterne JA, Lawlor DA. The effect of exercise in clinically depressed adults: systematic review and meta-analysis of randomized controlled trials. J Clin Psychiatry. 2011;72:529–38.

    Article  Google Scholar 

  5. Zhai L, Zhang Y, Zhang D. Sedentary behaviour and the risk of depression: a meta-analysis. Br J Sports Med. 2015;49:705–9.

    Article  Google Scholar 

  6. Li Y, Lv MR, Wei YJ, Sun L, Zhang JX, Zhang HG, et al. Dietary patterns and depression risk: A meta-analysis. Psychiatry Res. 2017;253:373–82.

    Article  Google Scholar 

  7. Li F, Liu X, Zhang D. Fish consumption and risk of depression: a meta-analysis. J Epidemiol Commun Health. 2016;70:299–4.

    Article  Google Scholar 

  8. Grosso G, Micek A, Marventano S, Castellano S, Mistretta A, Pajak A, et al. Dietary n-3 PUFA, fish consumption and depression: a systematic review and meta-analysis of observational studies. J Affect Disco. 2016;205:269–81.

    Article  CAS  Google Scholar 

  9. Su KP. Biological mechanism of antidepressant effect of omega-3 fatty acids: how does fish oil act as a “mind-body inerface”? Neurosignals. 2009;17:144–52.

    Article  CAS  Google Scholar 

  10. Tanskanen A, Hibbeln JR, Tuomilehto J, Uutela A, Haukkala A, Viinamaki H, et al. Fish consumption and depressive symptoms in the general population in Finland. Psychiatr Serv. 2001;52:529–31.

    Article  CAS  Google Scholar 

  11. Hakkarainen R, Partonen T, Haukka J, Virtamo J, Albanes D, Lonnqvist J. Is low dietary intake of omega-3 fatty acids associated with depression? Am J Psychiatry. 2004;161:567–69.

    Article  Google Scholar 

  12. Timonen M, Horrobin D, Jokelainen J, Laitinen J, Herva A, Rasanen P. Fish consumption and depression: the Northern Finland 1966 birth cohort study. J Affect Disco. 2004;82:447–52.

    Google Scholar 

  13. Barberger-Gateau P, Jutand MA, Letenneur L, Larrieu S, Tavernier B, Berr C. Correlates of regular fish consumption in French elderly community dwellers: data from the Three-City study. Eur J Clin Nutr. 2005;59:817–25.

    Article  CAS  Google Scholar 

  14. Kamphuis MH, Geerlings MI, Tijhuis MA, Kalmijn S, Grobbee DE, Kromhout D. Depression and cardiovascular mortality: a role for n-3 fatty acids? Am J Clin Nutr. 2006;84:1513–17.

    Article  CAS  Google Scholar 

  15. Astorg P, Couthouis A, Bertrais S, Arnault N, Meneton P, Guesnet P, et al. Association of fish and long-chain n-3 polyunsaturated fatty acid intakes with the occurrence of depressive episodes in middle-aged French men and women. Prostaglandins Leukot Essent Fattty Acids. 2008;78:171–82.

    Article  CAS  Google Scholar 

  16. Colangelo LA, He K, Whooley MA, Daviglus ML, Liu K. Higher dietary intake of long-chain omega-3 polyunsaturated fatty acids is inversely associated with depressive symptoms in women. Nutrition. 2009;25:1011–19.

    Article  CAS  Google Scholar 

  17. Suominen-Taipale AL, Partonen T, Turunen AW, Mannisto S, Jula A, Verkasalo PK. Fish consumption and omega-3 polyunsaturated fatty acids in relation to depressive episodes: a cross-sectional analysis. PLoS ONE. 2010;5:e10530.

    Article  Google Scholar 

  18. Chrysohoou C, Tsitsinakis G, Siassos G, Psaltopoulou T, Galiatsatos N, Metaxa V, et al. Fish consumption moderates depressive symptomatology in elderly men and women from the IKARIA Study. Cardiol Res Pract. 2011;2011:219578.

    Google Scholar 

  19. Li Y, Dai Q, Ekperi LI, Dehal A, Zhang J. Fish consumption and severely depressed mood, findings from the first national nutrition follow-up study. Psychiatry Res. 2011;190:103–9.

    Article  Google Scholar 

  20. Lucas M, Mirzaei F, O'Reilly EJ, Pan A, Willett WC, Kawachi I, et al. Dietary intake of n-3 and n-6 fatty acids and the risk of clinical depression in women: a 10-year prospective follow-up study. Am J Clin Nutr. 2011;93:1337–43.

    Article  CAS  Google Scholar 

  21. Albanese E, Lombardo FL, Dangour AD, Guerra M, Acosta D, Huang Y, et al. No association between fish intake and depression in over 15,000 older adults from seven low and middle income countries—the 10/66 study. PLoS ONE. 2012;7:e38879.

    Article  CAS  Google Scholar 

  22. Hoffmire CA, Block RC, Thevenet-Morrison K, van Wijngaarden E. Associations between omega-3 poly-unsaturated fatty acids from fish consumption and severity of depressive symptoms: an analysis of the 2005–2008 National Health and Nutrition Examination Survey. Prostaglandins Leukot Essent Fat Acids. 2012;86:155–60.

    Article  CAS  Google Scholar 

  23. Tsai AC, Chang TL, Chi SH. Frequent consumption of vegetables predicts lower risk of depression in older Taiwanese—results of a prospective population-based study. Public Health Nutr. 2012;15:1087–92.

    Article  Google Scholar 

  24. Smith KJ, Sanderson K, McNaughton SA, Gall SL, Dwyer T, Venn AJ. Longitudinal associations between fish consumption and depression in young adults. Am J Epidemiol. 2014;179:1228–35.

    Article  Google Scholar 

  25. Hamazaki K, Natori T, Kurihara S, Murata N, Cui ZG, Kigawa M, et al. Fish consumption and depressive symptoms in undergraduate students: a cross-sectional analysis. Eur Psychiatry. 2015;30:983–87.

    Article  CAS  Google Scholar 

  26. Wu D, Feng L, Gao Q, Li JL, Rajendran KS, Wong JC, et al. Association between fish intake and depressive symptoms among community-living older chinese adults in Singapore: a cross-sectional study. J Nutr Health Aging. 2016;20:404–7.

    Article  CAS  Google Scholar 

  27. Korea Center for Disease Control and Prevention Korea National Health and Nutrition Examination Survey. http://knhanes.cdc.go.kr. Accessed 10 Feb 2017.

  28. Kim DW, Song S, Lee JE, Oh K, Shim J, Kweon S, et al. Reproducibility and validity of an FFQ developed for the Korea National Health and Nutrition Examination Survey (KNHANES). Pub Health Nutr. 2015;18:1369–77.

    Article  Google Scholar 

  29. Berk M, Sarris J, Coulson CE, Jacka FN, Lifestyle management of unipolar depression. Acta Psychiatr Scand Suppl.2013;127:38–54.

    Article  Google Scholar 

  30. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000;32:S498–4.

    Article  CAS  Google Scholar 

  31. Yu M, Zhang X, Lu F, Fang L, Depression and risk for diabetes: a meta-analysis. Can J Diabetes. 2015;39:266–72.

    Article  Google Scholar 

  32. Wu Q, Kling JM. Depression and the risk of myocardial infarction and coronary death: a meta-analysis of prospective cohort studies. Medicine. 2016;95:e2815.

    Article  Google Scholar 

  33. Dong JY, Zhang YH, Tong J, Qin LQ. Depression and risk of stroke: a meta-analysis of prospective studies. Stroke. 2012;43:32–37.

    Article  Google Scholar 

  34. Chen YH, Lin HC. Increased risk of cancer subsequent to severe depression—a nationwide population-based study. J Affect Disco. 2011;131:200–6.

    Article  Google Scholar 

  35. Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr. 2004;80:1167–74.

    Article  CAS  Google Scholar 

  36. Delion S, Chalon S, Herault J, Guilloteau D, Besnard JC, Durand G. Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. J Nutr. 1994;124:2466–76.

    Article  CAS  Google Scholar 

  37. Arora RC, Meltzer HY. Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects. Am J Psychiatry. 1989;146:730–36.

    Article  CAS  Google Scholar 

  38. Stanley M, Mann JJ. Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet. 1983;1:214–16.

    Article  CAS  Google Scholar 

  39. Hibbeln JR, Linnoila M, Umhau JC, Rawlings R, George DT, Salem N Jr.. Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early and late-onset alcoholics. Biol Psychiatry. 1998;44:235–42.

    Article  CAS  Google Scholar 

  40. Bhattacharya A, Sun D, Rahman M, Fernandes G. Different ratios of eicosapentaenoic and docosahexaenoic omega-3 fatty acids in commercial fish oils differentially alter pro-inflammatory cytokines in peritoneal macrophages from C57BL/6 female mice. J Nutr Biochem. 2007;18:23–30.

    Article  CAS  Google Scholar 

  41. Heller A, Koch T, Schmeck J, van Ackern K. Lipid mediators in inflammatory disorders. Drugs. 1998;55:487–96.

    Article  CAS  Google Scholar 

  42. Valkanova V, Ebmeier KP, Allan CL. CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disco. 2013;150:736–44.

    Article  CAS  Google Scholar 

  43. Saada HN, Said UZ, Mahdy EM, Elmezayen HE, Shedid SM. Fish oil omega-3 fatty acids reduce the severity of radiation-induced oxidative stress in the rat brain. Int J Radiat Biol. 2014;90:1179–83.

    Article  CAS  Google Scholar 

  44. Black CN, Bot M, Scheffer PG, Cuijpers P, Penninx BW. Is depression associated with increased oxidative stress? A systematic review and meta-analysis. Psychoneuroendocrinology. 2015;51:164–75.

    Article  CAS  Google Scholar 

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Acknowledgements

We thank the participants and staff of the Korea Centers for Disease Control for their dedication and commitment. This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Science, ICT and Future Planning (NRF-2015R1A1A1A05001362). Funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funding

This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Science, ICT and Future Planning (NRF-2015R1A1A1A05001362). Funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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  1. Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea

    Yeonji Yang & Youjin Je

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  1. Yeonji Yang
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Correspondence to Youjin Je.

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Yang, Y., Je, Y. Fish consumption and depression in Korean adults: the Korea National Health and Nutrition Examination Survey, 2013–2015. Eur J Clin Nutr 72, 1142–1149 (2018). https://doi.org/10.1038/s41430-017-0083-9

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