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Vitamin D supplementation for the prevention of vitamin D deficiency after bariatric surgery: a systematic review and meta-analysis

European Journal of Clinical Nutrition volume 72, pages 1061–1070 (2018)Cite this article

Subjects

Abstract

Objective

To evaluate the efficacy of vitamin D supplementation on the prevention of postoperative vitamin D deficiency.

Methods

PubMed, Embase, Web of Science, and Cochrane library were searched. Prospective studies evaluating the effects of vitamin D supplementation in patients who had undergone bariatric surgery were included. Meta-regression was performed to explore heterogeneity, and assess the relationship between dosage of vitamin D supplementation, study design, and prevalence of vitamin D depletion.

Results

Twelve studies enrolling 1285 patients met the inclusion criteria, and were included. Vitamin D supplementation was associated with significant improvements in 1-year Vitamin D depletion and 1-year 25-OHD level. A daily supplement of more than 800 IU vitamin D significantly reduced the prevalence of 1-year Vitamin D depletion, but the dosage of less than 800 IU did not. Significant decrease in prevalence of 1-year Vitamin D depletion was observed in randomized controlled trials (RCTs), but not in non-RCTs. For the 1-year 25-OHD level, significant elevation was found in the studies irrespective of the study design and dosage of vitamin D supplementation. Meta-regression showed that there was significant relationship between vitamin D depletion and study design, but not between vitamin D depletion and the dosage of vitamin D supplementation.

Conclusion

Vitamin D supplementation with a daily dosage of more than 800 IU is effective in preventing postoperative vitamin D deficiency and improving the 25-OHD level. However, the results should be interpreted cautiously since there was significant heterogeneity among the studies.

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Authors and Affiliations

  1. Department of General Surgery, Peking University Third Hospital, Beijing, China

    Zhifei Li, Xin Zhou & Wei Fu

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  1. Zhifei Li
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Correspondence to Wei Fu.

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Li, Z., Zhou, X. & Fu, W. Vitamin D supplementation for the prevention of vitamin D deficiency after bariatric surgery: a systematic review and meta-analysis. Eur J Clin Nutr 72, 1061–1070 (2018). https://doi.org/10.1038/s41430-017-0059-9

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